Dietary fiber-derived short-chain fatty acids: A potential therapeutic target to alleviate obesity-related nonalcoholic fatty liver disease

Shumin Zhang, Jingwen Zhao, Fei Xie, Hengxun He, Lee J. Johnston, Xiaofeng Dai, Chaodong Wu, Xi Ma

Research output: Contribution to journalReview articlepeer-review

Abstract

Over the past several decades, increasing global prevalence of obesity-related nonalcoholic fatty liver disease (NAFLD) has been one of main challenges to human health. Recently, increasing evidence has validated connections among short chain fatty acids (SCFAs), a physiologically relevant concentration, the intestinal microbiota, and host metabolism. In this review, we summarized crosstalk between SCFAs and host metabolism in relation to NAFLD pathophysiology, focusing on recent advances. Firstly, how SCFAs are generated and absorbed under different nutritional conditions in the gut. Secondly, how SCFAs maintain gut barrier and alleviate hepatic inflammatory responses. Thirdly, how SCFAs maintain hepatic energy balance through controlling appetite and mediating the glucose homeostasis at the systemic level. Fourthly, G-protein-coupled receptors (GPRs) are widely involved in the above metabolic processes regulated by SCFAs. Overall, this review aimed to provide new insights into the prospects of SCFAs as a potential therapeutic target in management of liver diseases.

Original languageEnglish (US)
Article numbere13316
JournalObesity Reviews
Volume22
Issue number11
DOIs
StateAccepted/In press - 2021

Bibliographical note

Funding Information:
Our deep admiration and respect go to researchers in this field and in our laboratories for their dedication and hard work. We apologize to scientists whose work is in this field but their papers are not cited in this review owing to space limitations. This work was supported by the National Natural Science Foundation of China (31930106, 31829004, and 31722054), the 2115 Talent Development Program of China Agricultural University (1041?00109019), the National Key R&D Program of China (2018YFD0500601 and 2017YFD0500501), the National Ten-thousand Talents Program of China (23070201), and the 111 Project (B16044).

Funding Information:
Our deep admiration and respect go to researchers in this field and in our laboratories for their dedication and hard work. We apologize to scientists whose work is in this field but their papers are not cited in this review owing to space limitations. This work was supported by the National Natural Science Foundation of China (31930106, 31829004, and 31722054), the 2115 Talent Development Program of China Agricultural University (1041–00109019), the National Key R&D Program of China (2018YFD0500601 and 2017YFD0500501), the National Ten‐thousand Talents Program of China (23070201), and the 111 Project (B16044).

Publisher Copyright:
© 2021 World Obesity Federation

Keywords

  • NAFLD
  • SCFAs
  • dietary fiber
  • gut-liver axis

PubMed: MeSH publication types

  • Journal Article
  • Review

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