Dietary fiber-derived short-chain fatty acids: A potential therapeutic target to alleviate obesity-related nonalcoholic fatty liver disease

Shumin Zhang; Jingwen Zhao; Fei Xie; Hengxun He; Lee J. Johnston; Xiaofeng Dai; Chaodong Wu; Xi Ma

doi:10.1111/obr.13316

Dietary fiber-derived short-chain fatty acids: A potential therapeutic target to alleviate obesity-related nonalcoholic fatty liver disease

Shumin Zhang, Jingwen Zhao, Fei Xie, Hengxun He, Lee J. Johnston, Xiaofeng Dai, Chaodong Wu, Xi Ma

West Central Research and Outreach Center

Research output: Contribution to journal › Review article › peer-review

119 Scopus citations

Abstract

Over the past several decades, increasing global prevalence of obesity-related nonalcoholic fatty liver disease (NAFLD) has been one of main challenges to human health. Recently, increasing evidence has validated connections among short chain fatty acids (SCFAs), a physiologically relevant concentration, the intestinal microbiota, and host metabolism. In this review, we summarized crosstalk between SCFAs and host metabolism in relation to NAFLD pathophysiology, focusing on recent advances. Firstly, how SCFAs are generated and absorbed under different nutritional conditions in the gut. Secondly, how SCFAs maintain gut barrier and alleviate hepatic inflammatory responses. Thirdly, how SCFAs maintain hepatic energy balance through controlling appetite and mediating the glucose homeostasis at the systemic level. Fourthly, G-protein-coupled receptors (GPRs) are widely involved in the above metabolic processes regulated by SCFAs. Overall, this review aimed to provide new insights into the prospects of SCFAs as a potential therapeutic target in management of liver diseases.

Original language	English (US)
Article number	e13316
Journal	Obesity Reviews
Volume	22
Issue number	11
DOIs	https://doi.org/10.1111/obr.13316
State	Published - Nov 2021

Bibliographical note

Funding Information:
Our deep admiration and respect go to researchers in this field and in our laboratories for their dedication and hard work. We apologize to scientists whose work is in this field but their papers are not cited in this review owing to space limitations. This work was supported by the National Natural Science Foundation of China (31930106, 31829004, and 31722054), the 2115 Talent Development Program of China Agricultural University (1041?00109019), the National Key R&D Program of China (2018YFD0500601 and 2017YFD0500501), the National Ten-thousand Talents Program of China (23070201), and the 111 Project (B16044).

Funding Information:
Our deep admiration and respect go to researchers in this field and in our laboratories for their dedication and hard work. We apologize to scientists whose work is in this field but their papers are not cited in this review owing to space limitations. This work was supported by the National Natural Science Foundation of China (31930106, 31829004, and 31722054), the 2115 Talent Development Program of China Agricultural University (1041–00109019), the National Key R&D Program of China (2018YFD0500601 and 2017YFD0500501), the National Ten‐thousand Talents Program of China (23070201), and the 111 Project (B16044).

Publisher Copyright:
© 2021 World Obesity Federation.

Keywords

NAFLD
SCFAs
dietary fiber
gut-liver axis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/obr.13316

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title = "Dietary fiber-derived short-chain fatty acids: A potential therapeutic target to alleviate obesity-related nonalcoholic fatty liver disease",

abstract = "Over the past several decades, increasing global prevalence of obesity-related nonalcoholic fatty liver disease (NAFLD) has been one of main challenges to human health. Recently, increasing evidence has validated connections among short chain fatty acids (SCFAs), a physiologically relevant concentration, the intestinal microbiota, and host metabolism. In this review, we summarized crosstalk between SCFAs and host metabolism in relation to NAFLD pathophysiology, focusing on recent advances. Firstly, how SCFAs are generated and absorbed under different nutritional conditions in the gut. Secondly, how SCFAs maintain gut barrier and alleviate hepatic inflammatory responses. Thirdly, how SCFAs maintain hepatic energy balance through controlling appetite and mediating the glucose homeostasis at the systemic level. Fourthly, G-protein-coupled receptors (GPRs) are widely involved in the above metabolic processes regulated by SCFAs. Overall, this review aimed to provide new insights into the prospects of SCFAs as a potential therapeutic target in management of liver diseases.",

keywords = "NAFLD, SCFAs, dietary fiber, gut-liver axis",

author = "Shumin Zhang and Jingwen Zhao and Fei Xie and Hengxun He and Johnston, {Lee J.} and Xiaofeng Dai and Chaodong Wu and Xi Ma",

note = "Funding Information: Our deep admiration and respect go to researchers in this field and in our laboratories for their dedication and hard work. We apologize to scientists whose work is in this field but their papers are not cited in this review owing to space limitations. This work was supported by the National Natural Science Foundation of China (31930106, 31829004, and 31722054), the 2115 Talent Development Program of China Agricultural University (1041?00109019), the National Key R&D Program of China (2018YFD0500601 and 2017YFD0500501), the National Ten-thousand Talents Program of China (23070201), and the 111 Project (B16044). Funding Information: Our deep admiration and respect go to researchers in this field and in our laboratories for their dedication and hard work. We apologize to scientists whose work is in this field but their papers are not cited in this review owing to space limitations. This work was supported by the National Natural Science Foundation of China (31930106, 31829004, and 31722054), the 2115 Talent Development Program of China Agricultural University (1041–00109019), the National Key R&D Program of China (2018YFD0500601 and 2017YFD0500501), the National Ten‐thousand Talents Program of China (23070201), and the 111 Project (B16044). Publisher Copyright: {\textcopyright} 2021 World Obesity Federation.",

year = "2021",

month = nov,

doi = "10.1111/obr.13316",

language = "English (US)",

volume = "22",

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T2 - A potential therapeutic target to alleviate obesity-related nonalcoholic fatty liver disease

AU - Zhang, Shumin

AU - Zhao, Jingwen

AU - Xie, Fei

AU - He, Hengxun

AU - Johnston, Lee J.

AU - Dai, Xiaofeng

AU - Wu, Chaodong

AU - Ma, Xi

N1 - Funding Information: Our deep admiration and respect go to researchers in this field and in our laboratories for their dedication and hard work. We apologize to scientists whose work is in this field but their papers are not cited in this review owing to space limitations. This work was supported by the National Natural Science Foundation of China (31930106, 31829004, and 31722054), the 2115 Talent Development Program of China Agricultural University (1041?00109019), the National Key R&D Program of China (2018YFD0500601 and 2017YFD0500501), the National Ten-thousand Talents Program of China (23070201), and the 111 Project (B16044). Funding Information: Our deep admiration and respect go to researchers in this field and in our laboratories for their dedication and hard work. We apologize to scientists whose work is in this field but their papers are not cited in this review owing to space limitations. This work was supported by the National Natural Science Foundation of China (31930106, 31829004, and 31722054), the 2115 Talent Development Program of China Agricultural University (1041–00109019), the National Key R&D Program of China (2018YFD0500601 and 2017YFD0500501), the National Ten‐thousand Talents Program of China (23070201), and the 111 Project (B16044). Publisher Copyright: © 2021 World Obesity Federation.

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N2 - Over the past several decades, increasing global prevalence of obesity-related nonalcoholic fatty liver disease (NAFLD) has been one of main challenges to human health. Recently, increasing evidence has validated connections among short chain fatty acids (SCFAs), a physiologically relevant concentration, the intestinal microbiota, and host metabolism. In this review, we summarized crosstalk between SCFAs and host metabolism in relation to NAFLD pathophysiology, focusing on recent advances. Firstly, how SCFAs are generated and absorbed under different nutritional conditions in the gut. Secondly, how SCFAs maintain gut barrier and alleviate hepatic inflammatory responses. Thirdly, how SCFAs maintain hepatic energy balance through controlling appetite and mediating the glucose homeostasis at the systemic level. Fourthly, G-protein-coupled receptors (GPRs) are widely involved in the above metabolic processes regulated by SCFAs. Overall, this review aimed to provide new insights into the prospects of SCFAs as a potential therapeutic target in management of liver diseases.

AB - Over the past several decades, increasing global prevalence of obesity-related nonalcoholic fatty liver disease (NAFLD) has been one of main challenges to human health. Recently, increasing evidence has validated connections among short chain fatty acids (SCFAs), a physiologically relevant concentration, the intestinal microbiota, and host metabolism. In this review, we summarized crosstalk between SCFAs and host metabolism in relation to NAFLD pathophysiology, focusing on recent advances. Firstly, how SCFAs are generated and absorbed under different nutritional conditions in the gut. Secondly, how SCFAs maintain gut barrier and alleviate hepatic inflammatory responses. Thirdly, how SCFAs maintain hepatic energy balance through controlling appetite and mediating the glucose homeostasis at the systemic level. Fourthly, G-protein-coupled receptors (GPRs) are widely involved in the above metabolic processes regulated by SCFAs. Overall, this review aimed to provide new insights into the prospects of SCFAs as a potential therapeutic target in management of liver diseases.

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KW - dietary fiber

KW - gut-liver axis

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AN - SCOPUS:85110890608

SN - 1467-7881

VL - 22

JO - Obesity Reviews

JF - Obesity Reviews

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ER -

Dietary fiber-derived short-chain fatty acids: A potential therapeutic target to alleviate obesity-related nonalcoholic fatty liver disease

Abstract

Bibliographical note

Keywords

UN SDGs

Publisher link

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