Dietary Exposure of Japanese Quail (Coturnix japonica) to Perfluorooctane Sulfonate (PFOS) and a Legacy Aqueous Film-Forming Foam (AFFF) Containing PFOS: Effects on Reproduction and Chick Survivability and Growth

Steven J. Bursian, Jane E. Link, Michael Mccarty, Kendal Harr, John Roberts, Matt F. Simcik

Research output: Contribution to journalArticlepeer-review

Abstract

Effects of perfluorooctane sulfonate (PFOS) and a legacy aqueous film-forming foam (AFFF) containing 91% PFOS (AFFF PFOS) on reproduction, chick survivability, and growth of Japanese quail (Coturnix japonica) were determined. Day-old Japanese quail were administered PFOS or AFFF PFOS at 6 dietary concentrations ranging from 0 to 21 mg kg -1 feed for a total of 20 wk. At the age of 4 wk, 16 male/female pairs per treatment were assigned to cages, and egg laying was induced by the age of 10 wk. Eggs were collected daily, set weekly, and incubated for 18 d for the following 10 wk. Hatchlings were fed uncontaminated feed for 2 wk and euthanized to collect blood and liver. After 10 wk of egg collection, adults were euthanized to collect blood, liver, and kidneys. Significantly increased myofiber numbers in the liver and glomerular sclerosis in the kidneys of adults indicated damage at greater doses. Perfluorooctane sulfonate or AFFF PFOS did not significantly affect egg production; however, hatchability was decreased at the highest PFOS dose. The no-observed-adverse-effect levels for chick survivability, considered the critical effect, were 4.1 mg PFOS kg feed -1 (0.55 mg kg body wt -1  d -1 ) and 5.0 mg AFFF PFOS kg feed -1 (0.66 mg kg body wt -1  d -1 ), resulting in calculated average toxicity reference values of 0.25 mg kg feed -1 and 0.034 mg kg body weight -1  d -1 . Environ Toxicol Chem 2021;40:2521-2537. © 2020 SETAC.

Original languageEnglish (US)
Pages (from-to)2521-2537
Number of pages17
JournalEnvironmental Toxicology and Chemistry
Volume40
Issue number9
DOIs
StatePublished - Sep 2021

Bibliographical note

Funding Information:
Support for the present study was provided by the Strategic Environmental Research and Development Program under contract W912HQ‐16‐C‐0027 for Project ER‐2624: Development of Toxic Reference Values (TRVs) for Birds Exposed to PFOS, PFOA, and Associated Mixtures of Fluorinated Compounds.

Publisher Copyright:
© 2021 SETAC

Keywords

  • Aqueous film-forming foam
  • Avian toxicity
  • Japanese quail
  • Perfluoroalkyl substance
  • Perfluorooctane sulfonate

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