Dietary Clostridium butyricum Induces a Phased Shift in Fecal Microbiota Structure and Increases the Acetic Acid-Producing Bacteria in a Weaned Piglet Model

Jie Zhang, Xiyue Chen, Ping Liu, Jinbiao Zhao, Jian Sun, Wenyi Guan, Lee J. Johnston, Crystal L. Levesque, Peixin Fan, Ting He, Guolong Zhang, Xi Ma

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Clostridium butyricum is known as a butyrate producer and a regulator of gut health, but whether it exerts a beneficial effect as a dietary supplement via modulating the intestinal microbiota remains elusive. This study investigated the impact of C. butyricum on the fecal microbiota composition and their metabolites 14 and 28 days after weaning with 10 g/kg dietary supplementation of C. butyricum. Dynamic changes of microbial compositions showed dramatically increasing Selenomonadales and decreasing Clostridiales on days 14 and 28. Within Selenomonadales, Megasphaera became the main responder by increasing from 3.79 to 11.31%. Following the prevalence of some acetate producers (Magasphaera) and utilizers (Eubacterium-hallii) at the genus level and even with a significant decrease in fecal acetate on day 28, the present data suggested that C. butyricum influenced microbial metabolism by optimizing the structure of microbiota and enhancing acetate production and utilization for butyrate production.

Original languageEnglish (US)
Pages (from-to)5157-5166
Number of pages10
JournalJournal of agricultural and food chemistry
Volume66
Issue number20
DOIs
StatePublished - May 23 2018

Keywords

  • acetate production
  • Clostridium butyricum
  • fecal microbiota
  • phased shift
  • short chain fatty acid
  • weaned piglet

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