Dietary and supplemental long-chain n3 fatty acids and incident type 2 diabetes

Research output: Chapter in Book/Report/Conference proceedingChapter


Numerous studies have shown beneficial effects of dietary intake of fatty fish and seafood as well as long-chain n-3 fatty acid supplement use on coronary heart disease (CHD) and some risk factors for cardiovascular disease (CVD). Results are inconsistent for type 2 diabetes (T2D). Five meta-analyses, including up to 26 observational studies, have been published about the relation of fish and/or long-chain n-3 fatty acid consumption and risk of developing T2D; while no human intervention studies have been conducted testing the effectiveness of dietary or supplemental n-3 fatty acids on reducing the risk of T2D. Results of the main effects analysis showed no relation between dietary fish or n-3 fatty acids intakes with incident T2D. However, in subgroup analysis by geographic region, Asian consumers of n-3 fatty acids were at lower risk of developing T2D than Asian non-consumers; while no relation was observed in individuals living in western countries (USA and Europe).

Original languageEnglish (US)
Title of host publicationFish and Fish Oil in Health and Disease Prevention
PublisherElsevier Inc.
Number of pages6
ISBN (Print)9780128028445
StatePublished - Jul 27 2016


  • Intervention studies
  • Long-chain n-3 fatty acids
  • Meta-analysis
  • N-3 fatty acid supplement intake
  • Prospective studies
  • Type 2 diabetes


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