Diet quality and markers of endothelial function: The CARDIA study

F. P.C. Sijtsma, K. A. Meyer, Lyn M Steffen, L. Van Horn, J. M. Shikany, A. O. Odegaard, Myron D Gross, D. Kromhout, David R Jacobs Jr

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Background and aim: Dietary patterns are associated cross-sectionally with cellular adhesion molecules (CAMs). We studied prospective associations of three dietary patterns with CAMs. Methods and results: In the Coronary Artery Risk Development in Young Adults (CARDIA) study, diet was assessed at years 0 (1985-86) and 7 (1992-93) examinations. Four circulating CAMs (E-selectin, P-selectin, soluble intercellular adhesion molecule 1 (sICAM-1), and vascular cellular adhesion molecule (VCAM)) were assayed at years 7 and 15 (2000-01). We created one index score ". A Priori Diet Quality Score" and derived dietary patterns using principal components analysis (PCA). Multivariable linear regression models predicted year 15 CAMs from averaged (year 0/7) dietary patterns. The A Priori Diet Quality Score rated 46 food groups beneficial, neutral or adverse based on hypothesized health effects. We derived two PCA dietary patterns: "fruit and vegetables (FV)" (high intakes of fruit, vegetables, and whole grains) and "meat" (high intakes of red meat, refined grain, and butter). All dietary patterns were related to E-selectin and sICAM-1. P-selectin was not related to the FV dietary pattern. VCAM was only related to the A Priori Diet Quality Score. Strongest associations were for the meat dietary pattern with E-selectin (effect size 28% of an SD (+3.9/13.7ng/mL)) and P-selectin (effect size 37% of an SD (+4.1/11.2ng/mL)) and the A Priori Diet Quality Score with sICAM-1 (effect size 34% of an SD (-15.1/44.7ng/mL)) and VCAM (effect size of 26% of an SD (-45.1/170.3ng/mL)). Conclusion: This prospective analysis suggests that dietary patterns are associated with CAMs.

Original languageEnglish (US)
Pages (from-to)632-638
Number of pages7
JournalNutrition, Metabolism and Cardiovascular Diseases
Issue number6
StatePublished - Jun 2014

Bibliographical note

Funding Information:
Supported by contracts HHSN268201300025C, HHSN268201300026C, HHSN268201300027C, HHSN268201300028C, HHSN268201300029C, and HHSN268200900041C from the National Heart, Lung, and Blood Institute , grants R01-HL-53560 (YALTA), R01 HL093077 (Circulating CAMs and the Vasculature), and T32 HL07779 , and the Intramural Research Program of the National Institute on Aging.


  • Cellular adhesion molecules (CAMs)
  • Cohort
  • Diet
  • Endothelial function
  • Epidemiology


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