Diet patterns and the incidence of age-related macular degeneration in the Atherosclerosis Risk in Communities (ARIC) study

Shruti Dighe, Jiwei Zhao, Lyn Steffen, J. A. Mares, Stacy M. Meuer, Barbara E.K. Klein, Ronald Klein, Amy E. Millen

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Background Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss among the elderly. Objective This study aimed to determine the association between dietary patterns and food groups (used to make them) with the 18-year incidence of AMD. Methods ARIC (Atherosclerosis Risk in Communities) participants who showed change in AMD lesions between retinal photographs taken at visit 3 and visit 5 were graded side by side to determine incident AMD (any=144; early=117; late=27). A 66-line item food frequency questionnaire, administered at visit 1 and visit 3, was used to identify 29 food groups. Principal component analysis was used to derive dietary patterns from average food group servings. Logistic regression was used to estimate ORs and 95% CIs for incident AMD (any, early and late) by tertiles of dietary pattern scores, adjusted for age, race, education, total calories and smoking status. P-trend was estimated using continuous scores. Results Western (unhealthy) and Prudent (healthy) dietary patterns were identified. No significant associations were observed between either dietary pattern and incident any or incident early AMD. However, a threefold higher incidence of late AMD was observed among participants with a Western pattern score above, as compared with below, the median (OR=3.44 (95% CI 1.33 to 8.87), p-trend=0.014). The risk of developing late AMD was decreased, but not statistically significant, among participants with a Prudent pattern score above, as compared with below, the median (OR=0.51 (95% CI 0.22 to 1.18), p-trend=0.054). Conclusions Diet patterns were not significantly associated with incident any or incident early AMD. However, consumption of a Western pattern diet may be a risk factor for development of late AMD.

Original languageEnglish (US)
Pages (from-to)1070-1076
Number of pages7
JournalBritish Journal of Ophthalmology
Volume104
Issue number8
DOIs
StatePublished - Aug 1 2020

Bibliographical note

Funding Information:
This research is supported by the National Institutes of Health (NIH) National Institute on Aging grant number R01 AG041776. The Atherosclerosis Risk in Communities study has been funded in whole or in part with Federal funds from the National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services (contract numbers HHSN268201700001I, HHSN268201700002I, HHSN268201700003I, HHSN268201700004I and HHSN268201700005I). Neurocognitive data are collected by U012U01HL096812, 2U01HL096814, 2U01HL096899, 2U01HL096902 and 2U01HL096917 from the NIH (NHLBI, NINDS, NIA and NIDCD), and with previous brain MRI examinations funded by R01-HL70825 from the NHLBI. R01HL087641, R01HL086694; National Human Genome Research Institute contract U01HG004402; and National Institutes of Health contract HHSN268200625226C. Infrastructure was partly supported by Grant Number UL1RR025005, a component of the NIH and NIH Roadmap for Medical Research.

Publisher Copyright:
© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.

Keywords

  • Prudent pattern
  • Western pattern
  • dietary patterns
  • food groups
  • incident age-related macular degeneration
  • late age-related macular degeneration

PubMed: MeSH publication types

  • Journal Article
  • Multicenter Study
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

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