Diet-induced obesity and mammary tumor development in relation to estrogen receptor status

Amitabha Ray, Katai J. Nkhata, Joseph P. Grande, Margot P Cleary

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Leptin enhances proliferation of estrogen receptor (ER)-positive breast cancer cells in vitro. Here, we compared mammary tumor (MT) formation from ER-positive (MCF-7) and ER-negative (MDA-MB-231) breast cancer cells in athymic mice fed a High-Fat diet to elevate serum leptin. Neither body weight, diet or serum leptin levels impacted MT latency, burden or tumor grade. However, protein expression in mammary fat pads exhibited elevated PCNA and Cyclin D1 while in MTs, Ob-Rb, IGF-IR, Bcl-2, and Bax were lower in Low-Fat versus High-Fat mice. In conclusion, diet rather than serum leptin impacted breast cancer cell tumor metabolism.

Original languageEnglish (US)
Pages (from-to)291-300
Number of pages10
JournalCancer Letters
Volume253
Issue number2
DOIs
StatePublished - Aug 18 2007

Keywords

  • Breast
  • Cancer
  • Diet-induced obesity
  • Estrogen receptor
  • High-Fat diet
  • IGF-I
  • Leptin
  • Tumors

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