Diet effect on activity product ratios of uric acid, sodium urate, and ammonium urate in urine formed by healthy beagles.

J. W. Bartges, Carl A Osborne, L. J. Felice, T. A. Allen, C. Brown, L. K. Unger, L. A. Koehler, K. A. Bird, M. Chen

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Urine activity product ratios of uric acid, sodium urate, and ammonium urate and urinary excretion of metabolites were determined in 24-hour samples produced by 6 healthy Beagles during periods of consumption of a low-protein, casein-based diet (diet A) and a high-protein, meat-based diet (diet B). Comparison of effects of diet A with those of diet B revealed: significantly lower activity product ratios of uric acid (P = 0.025), sodium urate (P = 0.045), and ammonium urate (P = 0.0045); significantly lower 24-hour urinary excretion of uric acid (P = 0.002), ammonia (P = 0.0002), sodium (P = 0.01), calcium (P = 0.005), phosphorus (P = 0.0003), magnesium (P = 0.01), and oxalic acid (P = 0.004); significantly (P = 0.0001) higher 24-hour urine pH; and significantly (P = 0.01) lower endogenous creatinine clearance. These results suggest that consumption of diet A minimizes changes in urine that predispose dogs to uric acid, sodium urate, and ammonium urate urolithiasis.

Original languageEnglish (US)
Pages (from-to)329-333
Number of pages5
JournalAmerican journal of veterinary research
Volume56
Issue number3
StatePublished - Mar 1995

Fingerprint Dive into the research topics of 'Diet effect on activity product ratios of uric acid, sodium urate, and ammonium urate in urine formed by healthy beagles.'. Together they form a unique fingerprint.

Cite this