Diet drives convergence in gut microbiome functions across mammalian phylogeny and within humans

Brian D. Muegge, Justin Kuczynski, Dan Knights, Jose C. Clemente, Antonio González, Luigi Fontana, Bernard Henrissat, Rob Knight, Jeffrey I. Gordon

Research output: Contribution to journalArticle

926 Scopus citations

Abstract

Coevolution of mammals and their gut microbiota has profoundly affected their radiation into myriad habitats. We used shotgun sequencing of microbial community DNA and targeted sequencing of bacterial 16S ribosomal RNA genes to gain an understanding of how microbial communities adapt to extremes of diet. We sampled fecal DNA from 33 mammalian species and 18 humans who kept detailed diet records, and we found that the adaptation of the microbiota to diet is similar across different mammalian lineages. Functional repertoires of microbiome genes, such as those encoding carbohydrate-active enzymes and proteases, can be predicted from bacterial species assemblages. These results illustrate the value of characterizing vertebrate gut microbiomes to understand host evolutionary histories at a supraorganismal level.

Original languageEnglish (US)
Pages (from-to)970-974
Number of pages5
JournalScience
Volume332
Issue number6032
DOIs
StatePublished - May 20 2011

Fingerprint Dive into the research topics of 'Diet drives convergence in gut microbiome functions across mammalian phylogeny and within humans'. Together they form a unique fingerprint.

  • Cite this

    Muegge, B. D., Kuczynski, J., Knights, D., Clemente, J. C., González, A., Fontana, L., Henrissat, B., Knight, R., & Gordon, J. I. (2011). Diet drives convergence in gut microbiome functions across mammalian phylogeny and within humans. Science, 332(6032), 970-974. https://doi.org/10.1126/science.1198719