Diet and risk of colon cancer in a large prospective study of older women: An analysis stratified on family history (Iowa, United States)

Thomas A. Sellers; Amy E. Bazyk; Roberd M. Bostick; Lawrence H. Kushi; Janet E. Olson; Kristin E. Anderson; Deann Lazovich; Aaron R. Folsom

doi:10.1023/A:1008886715597

Diet and risk of colon cancer in a large prospective study of older women: An analysis stratified on family history (Iowa, United States)

Thomas A. Sellers, Amy E. Bazyk, Roberd M. Bostick, Lawrence H. Kushi, Janet E. Olson, Kristin E. Anderson, Deann Lazovich, Aaron R. Folsom

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114 Scopus citations

Abstract

Objective: The purpose was to investigate whether dietary associations with risk of colon cancer in women differ by family history of the disease. Methods: Data were analyzed from a prospective cohort study of 35,216 Iowa (United States) women aged 55 to 69 years at baseline. Through 31 December 1995, 241 colon cancers were identified through record linkage with the State Health Registry. The cohort was stratified on family history of colon cancer in first-degree relatives; nutrient intakes were divided into tertiles. Results: Analyses using Cox regression revealed that the association of most dietary components with colon cancer incidence were similar for individuals with and without a family history. However, total calcium intake was associated inversely with colon cancer among women with a negative family history (relative risk [RR] = 0.50 for upper cf lower tertile, P < 0.001), but was unrelated to incidence for women with a positive family history (RR = 1.1 for upper cf lower tertile, P = 0.69). Similarly, total vitamin E intake was associated with lower risk among women with a negative family history (RR = 0.67 for upper cf lower tertile, P = 0.04), but not among women with a positive family history (RR = 0.87 for upper cf lower tertile, P = 0.67). High intakes of fiber, fruits, and vegetables were each weakly inversely associated with risk among family-history negative women, but not among family-history positive women. Conclusions: These data, if corroborated, suggest that dietary factors typically associated with lower risk may be less effective risk-reduction interventions against colon cancer for individuals with a family history of colon cancer.

Original language	English (US)
Pages (from-to)	357-367
Number of pages	11
Journal	Cancer Causes and Control
Volume	9
Issue number	4
DOIs	https://doi.org/10.1023/A:1008886715597
State	Published - 1998

Bibliographical note

Funding Information:
Authors are with the Division of Epidemiology, University of Minnesota School of Public Health, (Drs Sellers, Bazyk, Kushi, Olson, Anderson, Lazovich, Folsom), and the University of Minnesota Cancer Center, (Drs Sellers, Kushi, Anderson, Lazovich, Folsom), Minneapolis, MN, USA. Dr Bostick is with the Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA. Address correspondence to Dr Sellers, Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA. This publication was supported by a grant (R01 CA39742) from the US National Cancer Institute. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Cancer Institute.

Keywords

Colon cancer
Diet
Family history
United States
Women

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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@article{88e5406be66f42d4bc0faa2c070e4943,

title = "Diet and risk of colon cancer in a large prospective study of older women: An analysis stratified on family history (Iowa, United States)",

abstract = "Objective: The purpose was to investigate whether dietary associations with risk of colon cancer in women differ by family history of the disease. Methods: Data were analyzed from a prospective cohort study of 35,216 Iowa (United States) women aged 55 to 69 years at baseline. Through 31 December 1995, 241 colon cancers were identified through record linkage with the State Health Registry. The cohort was stratified on family history of colon cancer in first-degree relatives; nutrient intakes were divided into tertiles. Results: Analyses using Cox regression revealed that the association of most dietary components with colon cancer incidence were similar for individuals with and without a family history. However, total calcium intake was associated inversely with colon cancer among women with a negative family history (relative risk [RR] = 0.50 for upper cf lower tertile, P < 0.001), but was unrelated to incidence for women with a positive family history (RR = 1.1 for upper cf lower tertile, P = 0.69). Similarly, total vitamin E intake was associated with lower risk among women with a negative family history (RR = 0.67 for upper cf lower tertile, P = 0.04), but not among women with a positive family history (RR = 0.87 for upper cf lower tertile, P = 0.67). High intakes of fiber, fruits, and vegetables were each weakly inversely associated with risk among family-history negative women, but not among family-history positive women. Conclusions: These data, if corroborated, suggest that dietary factors typically associated with lower risk may be less effective risk-reduction interventions against colon cancer for individuals with a family history of colon cancer.",

keywords = "Colon cancer, Diet, Family history, United States, Women",

author = "Sellers, {Thomas A.} and Bazyk, {Amy E.} and Bostick, {Roberd M.} and Kushi, {Lawrence H.} and Olson, {Janet E.} and Anderson, {Kristin E.} and Deann Lazovich and Folsom, {Aaron R.}",

note = "Funding Information: Authors are with the Division of Epidemiology, University of Minnesota School of Public Health, (Drs Sellers, Bazyk, Kushi, Olson, Anderson, Lazovich, Folsom), and the University of Minnesota Cancer Center, (Drs Sellers, Kushi, Anderson, Lazovich, Folsom), Minneapolis, MN, USA. Dr Bostick is with the Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA. Address correspondence to Dr Sellers, Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA. This publication was supported by a grant (R01 CA39742) from the US National Cancer Institute. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Cancer Institute.",

year = "1998",

doi = "10.1023/A:1008886715597",

language = "English (US)",

volume = "9",

pages = "357--367",

journal = "Cancer Causes and Control",

issn = "0957-5243",

publisher = "Springer Netherlands",

number = "4",

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TY - JOUR

T1 - Diet and risk of colon cancer in a large prospective study of older women

T2 - An analysis stratified on family history (Iowa, United States)

AU - Sellers, Thomas A.

AU - Bazyk, Amy E.

AU - Bostick, Roberd M.

AU - Kushi, Lawrence H.

AU - Olson, Janet E.

AU - Anderson, Kristin E.

AU - Lazovich, Deann

AU - Folsom, Aaron R.

N1 - Funding Information: Authors are with the Division of Epidemiology, University of Minnesota School of Public Health, (Drs Sellers, Bazyk, Kushi, Olson, Anderson, Lazovich, Folsom), and the University of Minnesota Cancer Center, (Drs Sellers, Kushi, Anderson, Lazovich, Folsom), Minneapolis, MN, USA. Dr Bostick is with the Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA. Address correspondence to Dr Sellers, Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA. This publication was supported by a grant (R01 CA39742) from the US National Cancer Institute. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Cancer Institute.

PY - 1998

Y1 - 1998

N2 - Objective: The purpose was to investigate whether dietary associations with risk of colon cancer in women differ by family history of the disease. Methods: Data were analyzed from a prospective cohort study of 35,216 Iowa (United States) women aged 55 to 69 years at baseline. Through 31 December 1995, 241 colon cancers were identified through record linkage with the State Health Registry. The cohort was stratified on family history of colon cancer in first-degree relatives; nutrient intakes were divided into tertiles. Results: Analyses using Cox regression revealed that the association of most dietary components with colon cancer incidence were similar for individuals with and without a family history. However, total calcium intake was associated inversely with colon cancer among women with a negative family history (relative risk [RR] = 0.50 for upper cf lower tertile, P < 0.001), but was unrelated to incidence for women with a positive family history (RR = 1.1 for upper cf lower tertile, P = 0.69). Similarly, total vitamin E intake was associated with lower risk among women with a negative family history (RR = 0.67 for upper cf lower tertile, P = 0.04), but not among women with a positive family history (RR = 0.87 for upper cf lower tertile, P = 0.67). High intakes of fiber, fruits, and vegetables were each weakly inversely associated with risk among family-history negative women, but not among family-history positive women. Conclusions: These data, if corroborated, suggest that dietary factors typically associated with lower risk may be less effective risk-reduction interventions against colon cancer for individuals with a family history of colon cancer.

AB - Objective: The purpose was to investigate whether dietary associations with risk of colon cancer in women differ by family history of the disease. Methods: Data were analyzed from a prospective cohort study of 35,216 Iowa (United States) women aged 55 to 69 years at baseline. Through 31 December 1995, 241 colon cancers were identified through record linkage with the State Health Registry. The cohort was stratified on family history of colon cancer in first-degree relatives; nutrient intakes were divided into tertiles. Results: Analyses using Cox regression revealed that the association of most dietary components with colon cancer incidence were similar for individuals with and without a family history. However, total calcium intake was associated inversely with colon cancer among women with a negative family history (relative risk [RR] = 0.50 for upper cf lower tertile, P < 0.001), but was unrelated to incidence for women with a positive family history (RR = 1.1 for upper cf lower tertile, P = 0.69). Similarly, total vitamin E intake was associated with lower risk among women with a negative family history (RR = 0.67 for upper cf lower tertile, P = 0.04), but not among women with a positive family history (RR = 0.87 for upper cf lower tertile, P = 0.67). High intakes of fiber, fruits, and vegetables were each weakly inversely associated with risk among family-history negative women, but not among family-history positive women. Conclusions: These data, if corroborated, suggest that dietary factors typically associated with lower risk may be less effective risk-reduction interventions against colon cancer for individuals with a family history of colon cancer.

KW - Colon cancer

KW - Diet

KW - Family history

KW - United States

KW - Women

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ER -

Diet and risk of colon cancer in a large prospective study of older women: An analysis stratified on family history (Iowa, United States)

Abstract

Bibliographical note

Keywords

UN SDGs

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