Abstract
We experimentally demonstrate dielectrophoretic concentration of biological analytes on the surface of a gold nanohole array, which concurrently acts as a nanoplasmonic sensor and gradient force generator. The combination of nanohole-enhanced dielectrophoresis, electroosmosis, and extraordinary optical transmission through the periodic gold nanohole array enables real-time label-free detection of analyte molecules in a 5 μL droplet using concentrations as low as 1 pM within a few minutes, which is more than 1000 times faster than purely diffusion-based binding. The nanohole-based optofluidic platform demonstrated here is straightforward to construct, applicable to both charged and neutral molecules, and performs a novel function that cannot be accomplished using conventional surface plasmon resonance sensors.
Original language | English (US) |
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Pages (from-to) | 2006-2012 |
Number of pages | 7 |
Journal | Nano letters |
Volume | 14 |
Issue number | 4 |
DOIs | |
State | Published - Apr 9 2014 |
Keywords
- Optofluidics
- dielectrophoresis
- extraordinary optical transmission
- mass transport
- nanohole array
- plasmonics
- surface plasmon resonance