Diazepam-induced feeding in captive gray wolves (Canis lupus)

Terry J. Kreeger; Allen S. Levine; Ulysses S. Seal; Margaret Callahan; Mark Beckel

doi:10.1016/0091-3057(91)90127-N

Diazepam-induced feeding in captive gray wolves (Canis lupus)

Terry J. Kreeger, Allen S. Levine, Ulysses S. Seal, Margaret Callahan, Mark Beckel

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5 Scopus citations

Abstract

Diazepam doses of 0.2, 0.4, and 0.8 mg/kg induced feeding in sated gray wolves in a dose-dependent manner (p<0.001). Neither 0.8 mg/kg of the benzodiazepine antagonist, β-CCP (p =0.36), nor 0.8 mg/kg of the benzodiazepine inverse agonist, β-CCE (p = 0.85), decreased the diazepam-induced hyperphagia. Five of 6 naive wolves (p = 0.003) ate dry dog food within 15.4 ± 1.9 min of being given 0.4 mg/kg diazepam and freely chose dog food after the single diazepam administration.

Original language	English (US)
Pages (from-to)	559-561
Number of pages	3
Journal	Pharmacology, Biochemistry and Behavior
Volume	39
Issue number	3
DOIs	https://doi.org/10.1016/0091-3057(91)90127-N
State	Published - Jul 1991

Keywords

Benzodiazepines
Diazepam
Eating
Feeding behavior
Gray wolf
β-Carbolines

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10.1016/0091-3057(91)90127-N

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title = "Diazepam-induced feeding in captive gray wolves (Canis lupus)",

abstract = "Diazepam doses of 0.2, 0.4, and 0.8 mg/kg induced feeding in sated gray wolves in a dose-dependent manner (p<0.001). Neither 0.8 mg/kg of the benzodiazepine antagonist, β-CCP (p =0.36), nor 0.8 mg/kg of the benzodiazepine inverse agonist, β-CCE (p = 0.85), decreased the diazepam-induced hyperphagia. Five of 6 naive wolves (p = 0.003) ate dry dog food within 15.4 ± 1.9 min of being given 0.4 mg/kg diazepam and freely chose dog food after the single diazepam administration.",

keywords = "Benzodiazepines, Diazepam, Eating, Feeding behavior, Gray wolf, β-Carbolines",

author = "Kreeger, {Terry J.} and Levine, {Allen S.} and Seal, {Ulysses S.} and Margaret Callahan and Mark Beckel",

year = "1991",

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doi = "10.1016/0091-3057(91)90127-N",

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T1 - Diazepam-induced feeding in captive gray wolves (Canis lupus)

AU - Kreeger, Terry J.

AU - Levine, Allen S.

AU - Seal, Ulysses S.

AU - Callahan, Margaret

AU - Beckel, Mark

PY - 1991/7

Y1 - 1991/7

N2 - Diazepam doses of 0.2, 0.4, and 0.8 mg/kg induced feeding in sated gray wolves in a dose-dependent manner (p<0.001). Neither 0.8 mg/kg of the benzodiazepine antagonist, β-CCP (p =0.36), nor 0.8 mg/kg of the benzodiazepine inverse agonist, β-CCE (p = 0.85), decreased the diazepam-induced hyperphagia. Five of 6 naive wolves (p = 0.003) ate dry dog food within 15.4 ± 1.9 min of being given 0.4 mg/kg diazepam and freely chose dog food after the single diazepam administration.

AB - Diazepam doses of 0.2, 0.4, and 0.8 mg/kg induced feeding in sated gray wolves in a dose-dependent manner (p<0.001). Neither 0.8 mg/kg of the benzodiazepine antagonist, β-CCP (p =0.36), nor 0.8 mg/kg of the benzodiazepine inverse agonist, β-CCE (p = 0.85), decreased the diazepam-induced hyperphagia. Five of 6 naive wolves (p = 0.003) ate dry dog food within 15.4 ± 1.9 min of being given 0.4 mg/kg diazepam and freely chose dog food after the single diazepam administration.

KW - Benzodiazepines

KW - Diazepam

KW - Eating

KW - Feeding behavior

KW - Gray wolf

KW - β-Carbolines

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U2 - 10.1016/0091-3057(91)90127-N

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SN - 0091-3057

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EP - 561

JO - Pharmacology, Biochemistry and Behavior

JF - Pharmacology, Biochemistry and Behavior

IS - 3

ER -

Diazepam-induced feeding in captive gray wolves (Canis lupus)

Abstract

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