Diazepam-induced feeding in captive gray wolves (Canis lupus)

Terry J. Kreeger, Allen S. Levine, Ulysses S. Seal, Margaret Callahan, Mark Beckel

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Diazepam doses of 0.2, 0.4, and 0.8 mg/kg induced feeding in sated gray wolves in a dose-dependent manner (p<0.001). Neither 0.8 mg/kg of the benzodiazepine antagonist, β-CCP (p =0.36), nor 0.8 mg/kg of the benzodiazepine inverse agonist, β-CCE (p = 0.85), decreased the diazepam-induced hyperphagia. Five of 6 naive wolves (p = 0.003) ate dry dog food within 15.4 ± 1.9 min of being given 0.4 mg/kg diazepam and freely chose dog food after the single diazepam administration.

Original languageEnglish (US)
Pages (from-to)559-561
Number of pages3
JournalPharmacology, Biochemistry and Behavior
Volume39
Issue number3
DOIs
StatePublished - Jul 1991

Keywords

  • Benzodiazepines
  • Diazepam
  • Eating
  • Feeding behavior
  • Gray wolf
  • β-Carbolines

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