Diatrizoate in computed cranial tomography: A quantitative study

I. E. Lepplk, C. J. Thompson, R. Ethier, A. L. Sherw1n

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Plasma diatrizoate concentrations during computed cranial tomography were measured by UV spectrophotometry in 14 patients. A loading dose of 0.82 mg diatrizoate/kg followed by a steady infusion of 0.01 mg/kg was required to attain and maintain plasma concentrations of approximately 400 mg/100 ml. Lowering the beam energy resulted in a substantial increase in the EMI numbers of diatrizoate and significant improvement in the delineation of contrast containing lesions. A contrast index estimating the volume of a pixel containing diatrizoate was calculated for five diagnosed lesions and this factor appears to be related to vascularity and extravasation.

Original languageEnglish (US)
Pages (from-to)21-26
Number of pages6
JournalInvestigative Radiology
Issue number1
StatePublished - 1977


  • Brain
  • CT scan
  • Computed cranial tomography
  • Diatrizoate
  • EMI scan


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