Diastolic dysfunction: Potential new diagnostics and therapies

Euy Myoung Jeong, Samuel C. Dudley

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Despite the growing number of patients affected, the understanding of diastolic dysfunction and heart failure with preserved ejection fraction (HFpEF) is still poor. Clinical trials, largely based on successful treatments for systolic heart failure, have been disappointing, suggesting that HFpEF has a different pathology to that of systolic dysfunction. In this review, general concepts, epidemiology, diagnosis, and treatment of diastolic dysfunction are summarized, with an emphasis on new experiments suggesting that oxidative stress plays a crucial role in the pathogenesis of at least some forms of the disease. This observation has lead to potential new diagnostics and therapeutics for diastolic dysfunction and heart failure caused by diastolic dysfunction.

Original languageEnglish (US)
Pages (from-to)470-477
Number of pages8
JournalCirculation Journal
Volume79
Issue number3
DOIs
StatePublished - 2015

Keywords

  • Diastolic dysfunction
  • Heart failure
  • Myofilament Ca sensitivity
  • Oxidative stress
  • Ventricular relaxation

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