Diastereoselective Intramolecular Cyanoamidation with Alkenes

Ashley M. Dreis, Sadie C. Otte, Matthew S. Eastwood, Elizabeth R. Alonzi, Jason T. Brethorst, Christopher J. Douglas

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Reported herein is a diastereoselective intramolecular alkene cyanoamidation, wherein high d.r. values are imparted by chiral directing groups. Lactams with an α-all-carbon quaternary stereocenter are readily synthesized, which may enable access to structures frequently found in biologically active molecules and natural products.

Original languageEnglish (US)
Pages (from-to)45-48
Number of pages4
JournalEuropean Journal of Organic Chemistry
Issue number1
StatePublished - Jan 3 2017

Bibliographical note

Publisher Copyright:
© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim


  • Bond Activation
  • Cyanoamidation
  • Diastereoselectivity
  • Homogeneous catalysis
  • Palladium


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