Diastereoselective dihydroxylation and regioselective deoxygenation of dihydropyranones: A novel protocol for the stereoselective synthesis of C 1-C8 and C15-C21 subunits of (+)-discodermolide

P. Veeraraghavan Ramachandran, Bodhuri Prabhudas, J. Subash Chandra, M. Venkat Ram Reddy

Research output: Contribution to journalArticlepeer-review

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Abstract

Diastereoselective dihydroxylation of dihydropyranones and subsequent regioselective α-deoxygenation provides 1,3-trans-β-hydroxy-6- lactones stereoselectively. This protocol has been applied for the synthesis of C1-C8 and C15-C21 subunits of (+)-discodermolide.

Original languageEnglish (US)
Pages (from-to)6294-6304
Number of pages11
JournalJournal of Organic Chemistry
Volume69
Issue number19
DOIs
StatePublished - Sep 17 2004

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