Abstract
Diastereoselective dihydroxylation of dihydropyranones and subsequent regioselective α-deoxygenation provides 1,3-trans-β-hydroxy-6- lactones stereoselectively. This protocol has been applied for the synthesis of C1-C8 and C15-C21 subunits of (+)-discodermolide.
Original language | English (US) |
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Pages (from-to) | 6294-6304 |
Number of pages | 11 |
Journal | Journal of Organic Chemistry |
Volume | 69 |
Issue number | 19 |
DOIs | |
State | Published - Sep 17 2004 |