Diagnostic strategy and timing of intervention in infected necrotizing pancreatitis: an international expert survey and case vignette study

Janneke van Grinsven, Sandra van Brunschot, Paul Fockens, Janneke van Grinsven, Olaf J. Bakker, Hjalmar C. van Santvoort, Thomas L. Bollen, Marja A. Boermeester, Hjalmar C. van Santvoort, Marc G. Besselink, Marco J. Bruno, Cornelis H. Dejong, Marcel G. Dijkgraaf, Casper H. van Eijck, Harry van Goor, Hein G. Gooszen, Karen D. Horvath, Krijn P. van Lienden, M. Abdelhafez, R. AnderssonA. Andren-Sandberg, S. Ashley, M. van Baal, T. Baron, C. Bassi, E. Bradley, M. Buchler, V. Cappendijk, R. Carter, R. Charnley, D. Coelho, S. Connor, P. Dellinger, C. Dervenis, J. Deviere, N. Doctor, V. Dudeja, M. En-qiang, J. Escourrou, P. Fagenholz, G. Farkas, C. Forsmark, M. Freeman, P. Freeny, J. French, H. Friess, T. Gardner, P. Goetzinger, J. Haveman, S. Hofker, Dutch Pancreatitis Study Group, Dutch Pancreatitis Study Group

Research output: Contribution to journalArticlepeer-review

70 Scopus citations


Background The optimal diagnostic strategy and timing of intervention in infected necrotizing pancreatitis is subject to debate. We performed a survey on these topics amongst a group of international expert pancreatologists. Methods An online survey including case vignettes was sent to 118 international pancreatologists. We evaluated the use and timing of fine needle aspiration (FNA), antibiotics, catheter drainage and (minimally invasive) necrosectomy. Results The response rate was 74% (N = 87). None of the respondents use FNA routinely, 85% selectively and 15% never. Most respondents (87%) use a step-up approach in patients with infected necrosis. Walled-off necrosis (WON) is considered a prerequisite for endoscopic drainage and percutaneous drainage by 66% and 12%, respectively. After diagnosing infected necrosis, 55% routinely postpone invasive interventions, whereas 45% proceed immediately to intervention. Lack of consensus about timing of intervention was apparent on day 14 with proven infected necrosis (58% intervention vs. 42% non-invasive) as well as on day 20 with only clinically suspected infected necrosis (59% intervention vs. 41% non-invasive). Discussion The step-up approach is the preferred treatment strategy in infected necrotizing pancreatitis amongst expert pancreatologists. There is no uniformity regarding the use of FNA and timing of intervention in the first 2–3 weeks of infected necrotizing pancreatitis.

Original languageEnglish (US)
Pages (from-to)49-56
Number of pages8
Issue number1
StatePublished - 2016

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© 2015 International Hepato-Pancreato-Biliary Association Inc.


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