Diagnostic endoscopy in children after hematopoietic stem cell transplantation

Khalid Khan, Sarah Jane Schwarzenberg, Harvey Sharp, Jose Jessurun, H. Evin Gulbahce, Todd DeFor, Rajaram Nagarajan

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Objective: To determine the diagnostic yield versus complications from endoscopy in children after hematopoietic stem cell transplantation (HSCT). Design: Data from 191 patients were reviewed, then separated into procedures within the first 100 days after HSCT (when the risks for complications and prevalence of acute graft-versus-host disease [GVHD] are highest) and those performed beyond 100 days. Results: Visible endoscopic lesions were found in 63 of 198 (32%) esophagogastroduodenoscopies (EGDs) and 36 of 220 (16%) sigmoidoscopies. Acute GVHD was present in 38 of 121 (31%) biopsy specimens from EGDs within the first 100 days, 15 of 73 (21%) samples from EGDs after 100 days, 52 of 136 (38%) sigmoid biopsy specimens before 100 days, and in 25 of 82 (31%) samples after 100 days. Non-GVHD histologic abnormalities were present in 36 of 124 (29%) biopsy samples from EGDs before 100 days, 32 of 74 (43%) specimens after 100 days, 14 of 136 (10%) sigmoid specimens before 100 days, and 11 of 84 (13%) samples beyond 100 days. Complications: Complications occurred in 13 procedures (3.1%): 8 (4.2%) EGDs, 4 (2.0%) sigmoidoscopies, and 1 (5.5%) colonoscopy. Intestinal bleeding occurred in 12 of the 13 procedures. Thrombocytopenia was a statistically significant association (p < 0.01). One death occurred after splenic flexure perforation. Conclusions: GI abnormalities other than acute GVHD occurred in children after HSCT. Acute GVHD was diagnosed most commonly on sigmoid biopsy. Postprocedure hemorrhage was related to thrombocytopenia.

Original languageEnglish (US)
Pages (from-to)379-385
Number of pages7
JournalGastrointestinal endoscopy
Volume64
Issue number3
DOIs
StatePublished - Sep 2006

Bibliographical note

Funding Information:
Grant support for this study was provided by the Bone Marrow Transplant Research Fund Award from the Bone Marrow Transplant Research Fund (University of Minnesota).

Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.

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