Abstract
Antigen testing is an important diagnostic tool for histoplasmosis but has limited availability globally. We evaluated the OIDx urine lateral flow antigen assay among 204 persons suspected to have histoplasmosis. Among patients with proven histoplasmosis, sensitivity was 33.3% (3/9, 95% CI 7.5%–70.1%) and specificity 80.5% (157/195, 95% CI 74.3%–85.8%). The MiraVista urine antigen test had better specificity (96.9%) and equal sensitivity. The OIDx test demonstrated 33.3% (3/9) positive agreement and 84.0% (163/194) negative agreement with the MiraVista test. These results should be considered in the context of our low HIV prevalence population with a mixture of pulmonary and disseminated disease.
| Original language | English (US) |
|---|---|
| Article number | myae051 |
| Journal | Medical Mycology |
| Volume | 62 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 1 2024 |
Bibliographical note
Publisher Copyright:© The Author(s) 2024. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. All rights reserved.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Histoplasma capsulatum
- diagnostic test
- endemic mycoses
- histoplasmosis
- lateral flow assay
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