Diagnosis of fetal infections

Janet I. Andrews

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


Purpose of review: The purpose of this review is to present recent developments in the prenatal diagnosis of the most clinically relevant congenital infections. Recent findings: Immunoglobin G avidity testing can help to differentiate between recent or prior infection. A combination of tests, including serology, avidity and polymerase chain reaction, may be necessary to improve accuracy of diagnosis. The interval between exposure to an infectious agent and prenatal testing can be critical to the interpretation of the test result. Summary: This review reinforces the need for accurate testing to guide appropriate counseling and individual fetal risk assessment. The findings of viral-specific antibodies or sonographic abnormalities do not accurately predict the severity or outcome of fetal infection. Further research is necessary to determine the pathogenesis of transplacental viral transmission and thereby allow us to target prevention strategies.

Original languageEnglish (US)
Pages (from-to)163-166
Number of pages4
JournalCurrent Opinion in Obstetrics and Gynecology
Issue number2
StatePublished - Apr 2004
Externally publishedYes


  • Avidity testing
  • Fetal infections
  • Prenatal diagnosis


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