Diagnosis, classification, and course of myelodysplastic syndromes

R. W. McKenna, P. M. Allison

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


The myelodysplastic syndromes are bone marrow stem cell disorders that result in disorderly and ineffective hematopoiesis. They are prognostically heterogenous. Approximately one third of cases evolve to acute myeloid leukemia. Many additional cases terminate in severe bone marrow failure. The French-American-British Working Group classification of the myelodysplastic syndromes defines morphologic and prognostic groups. Cytogenetic and in vitro cell culture characteristics are important prognostic indicators.

Original languageEnglish (US)
Pages (from-to)683-706
Number of pages24
JournalClinics in Laboratory Medicine
Issue number4
StatePublished - 1990
Externally publishedYes


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