Diagnosis and management of central nervous system cryptococcal infections in HIV-infected adults

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16 Scopus citations


Cryptococcal meningitis persists as a significant source of morbidity and mortality in persons with HIV/AIDS, particularly in sub-Saharan Africa. Despite increasing access to antiretrovirals, persons presenting with advanced HIV disease remains common, and Cryptococcus remains the most frequent etiology of adult meningitis. We performed a literature review and herein present the most up-to-date information on the diagnosis and management of cryptococcosis. Recent advances have dramatically improved the accessibility of timely and affordable diagnostics. The optimal initial antifungal management has been newly updated after the completion of a landmark clinical trial. Beyond antifungals, the control of intracranial pressure and mitigation of toxicities remain hallmarks of effective treatment. Cryptococcal meningitis continues to present challenging complications and continued research is needed.

Original languageEnglish (US)
Article number65
JournalJournal of Fungi
Issue number3
StatePublished - Sep 2019

Bibliographical note

Funding Information:
Funding: Skipper is supported by the National Institute of Allergy and Infectious Diseases (T32AI055433).

Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.


  • AIDS
  • Antifungal therapy
  • Cryptococcal meningitis
  • Cryptococcus
  • HIV


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