Diabetic nephropathy. A perspective

Michael Mauer, Michael W Steffes, F. C. Goetz, D. E. Sutherland, D. M. Brown

Research output: Contribution to journalReview article

26 Citations (Scopus)

Abstract

The earliest manifestations of clinical diabetic nephropathy, including proteinuria, hypertension, and declining GFR, represent very advanced diabetic glomerulopathy with especially prominent mesangial expansion. Mesangial expansion, by restricting glomerular capillary filtration surface and lumenal volume, stimulates compensatory mechanisms analogous to those resulting from a marked reduction in nephron number. These compensatory mechanisms involve alterations in glomerular hemodynamics designed to maintain glomerular filtration but which ultimately injure the kidney. These hemodynamic perturbations are not specific to diabetes but represents a final common pathway toward endstage renal failure that also characterizes the remnant kidney. This thesis concludes that the onset of clinical diabetic nephropathy augurs inevitable decline in kidney function, and that only studies and interventions exercised before clinical nephropathy develops can influence understanding and outcome of diabetic nephropathy.

Original languageEnglish (US)
Pages (from-to)52-55
Number of pages4
JournalDiabetes
Volume32
Issue number2 II Suppl.
StatePublished - Jul 21 1983

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Diabetic Nephropathies
Kidney
Hemodynamics
Nephrons
Proteinuria
Renal Insufficiency
Hypertension

Cite this

Mauer, M., Steffes, M. W., Goetz, F. C., Sutherland, D. E., & Brown, D. M. (1983). Diabetic nephropathy. A perspective. Diabetes, 32(2 II Suppl.), 52-55.

Diabetic nephropathy. A perspective. / Mauer, Michael; Steffes, Michael W; Goetz, F. C.; Sutherland, D. E.; Brown, D. M.

In: Diabetes, Vol. 32, No. 2 II Suppl., 21.07.1983, p. 52-55.

Research output: Contribution to journalReview article

Mauer, M, Steffes, MW, Goetz, FC, Sutherland, DE & Brown, DM 1983, 'Diabetic nephropathy. A perspective', Diabetes, vol. 32, no. 2 II Suppl., pp. 52-55.
Mauer M, Steffes MW, Goetz FC, Sutherland DE, Brown DM. Diabetic nephropathy. A perspective. Diabetes. 1983 Jul 21;32(2 II Suppl.):52-55.
Mauer, Michael ; Steffes, Michael W ; Goetz, F. C. ; Sutherland, D. E. ; Brown, D. M. / Diabetic nephropathy. A perspective. In: Diabetes. 1983 ; Vol. 32, No. 2 II Suppl. pp. 52-55.
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