Diabetes increases excretion of urinary malonaldehyde conjugates in rats

Daniel D. Gallaher; A. Saari Csallany; Don W. Shoeman; Judith M. Olson

doi:10.1007/BF02536063

Diabetes increases excretion of urinary malonaldehyde conjugates in rats

Daniel D. Gallaher, A. Saari Csallany, Don W. Shoeman, Judith M. Olson

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Abstract

The effect of streptozotocin-induced diabetes on the urinary excretion of thiobarbituric acid test-positive materials was examined. In diabetic rats, urinary excretion of thiobarbituric acid reactive substances was increased 5-fold over that in nondiabetic animals. High-performance liquid chromatography of urine samples revealed that five of the six fractions previously found to be increased in vitamin E deficiency [Lee, H.-S., Shoeman, D.W., and Csallany, A.S. (1992)Lipids 27, 124-128] were also significantly increased in streptozotocin-induced diabetes. The data suggest that a high level of oxidative stress is induced by uncontrolled diabetes in rats.

Original language	English (US)
Pages (from-to)	663-666
Number of pages	4
Journal	Lipids
Volume	28
Issue number	7
DOIs	https://doi.org/10.1007/BF02536063
State	Published - Jul 1993

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title = "Diabetes increases excretion of urinary malonaldehyde conjugates in rats",

abstract = "The effect of streptozotocin-induced diabetes on the urinary excretion of thiobarbituric acid test-positive materials was examined. In diabetic rats, urinary excretion of thiobarbituric acid reactive substances was increased 5-fold over that in nondiabetic animals. High-performance liquid chromatography of urine samples revealed that five of the six fractions previously found to be increased in vitamin E deficiency [Lee, H.-S., Shoeman, D.W., and Csallany, A.S. (1992)Lipids 27, 124-128] were also significantly increased in streptozotocin-induced diabetes. The data suggest that a high level of oxidative stress is induced by uncontrolled diabetes in rats.",

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year = "1993",

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T1 - Diabetes increases excretion of urinary malonaldehyde conjugates in rats

AU - Gallaher, Daniel D.

AU - Csallany, A. Saari

AU - Shoeman, Don W.

AU - Olson, Judith M.

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N2 - The effect of streptozotocin-induced diabetes on the urinary excretion of thiobarbituric acid test-positive materials was examined. In diabetic rats, urinary excretion of thiobarbituric acid reactive substances was increased 5-fold over that in nondiabetic animals. High-performance liquid chromatography of urine samples revealed that five of the six fractions previously found to be increased in vitamin E deficiency [Lee, H.-S., Shoeman, D.W., and Csallany, A.S. (1992)Lipids 27, 124-128] were also significantly increased in streptozotocin-induced diabetes. The data suggest that a high level of oxidative stress is induced by uncontrolled diabetes in rats.

AB - The effect of streptozotocin-induced diabetes on the urinary excretion of thiobarbituric acid test-positive materials was examined. In diabetic rats, urinary excretion of thiobarbituric acid reactive substances was increased 5-fold over that in nondiabetic animals. High-performance liquid chromatography of urine samples revealed that five of the six fractions previously found to be increased in vitamin E deficiency [Lee, H.-S., Shoeman, D.W., and Csallany, A.S. (1992)Lipids 27, 124-128] were also significantly increased in streptozotocin-induced diabetes. The data suggest that a high level of oxidative stress is induced by uncontrolled diabetes in rats.

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Diabetes increases excretion of urinary malonaldehyde conjugates in rats

Abstract

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