Diabetes increases excretion of urinary malonaldehyde conjugates in rats

Daniel D. Gallaher, A. Saari Csallany, Don W. Shoeman, Judith M. Olson

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

The effect of streptozotocin-induced diabetes on the urinary excretion of thiobarbituric acid test-positive materials was examined. In diabetic rats, urinary excretion of thiobarbituric acid reactive substances was increased 5-fold over that in nondiabetic animals. High-performance liquid chromatography of urine samples revealed that five of the six fractions previously found to be increased in vitamin E deficiency [Lee, H.-S., Shoeman, D.W., and Csallany, A.S. (1992)Lipids 27, 124-128] were also significantly increased in streptozotocin-induced diabetes. The data suggest that a high level of oxidative stress is induced by uncontrolled diabetes in rats.

Original languageEnglish (US)
Pages (from-to)663-666
Number of pages4
JournalLipids
Volume28
Issue number7
DOIs
StatePublished - Jul 1993

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