Diabetes following acute pancreatitis

Phil A. Hart, David Bradley, Darwin L. Conwell, Kathleen Dungan, Somashekar G. Krishna, Kathleen Wyne, Melena D. Bellin, Dhiraj Yadav, Dana K. Andersen, Jose Serrano, Georgios I. Papachristou

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


Diabetes represents a group of diseases involving persistent hyperglycaemia. Exocrine disorders of the pancreas are increasingly recognised to cause or precede the onset of diabetes, which in this context is referred to as pancreatogenic or type 3c diabetes. Diabetes, as a sequela of acute pancreatitis, is observed across the spectrum of severity in acute pancreatitis and can be associated with other clinical complications. The pathophysiology of acute pancreatitis-related diabetes is poorly understood, and observations suggest that it is probably multifactorial. In this Review, we discuss the epidemiology, pathophysiology, and management considerations of diabetes following acute pancreatitis, and highlight knowledge gaps in this topic.

Original languageEnglish (US)
Pages (from-to)668-675
Number of pages8
JournalThe Lancet Gastroenterology and Hepatology
Issue number8
StatePublished - Aug 2021

Bibliographical note

Funding Information:
Research reported in this publication was supported by the National Cancer Institute and National Institute of Diabetes and Digestive and Kidney Diseases under award numbers U01DK127388 (PAH, DB, DLC, KD, GIP), U01DK108327 (PAH, DB, DLC), U01DK126300 (MDB), U01DK127367 (MDB), U01DK108306 (DY), and U01DK127377 (DY). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Publisher Copyright:
© 2021 Elsevier Ltd


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