Diabetes and vascular disease: Basic concepts of nitric oxide physiology, endothelial dysfunction, oxidative stress and therapeutic possibilities

Verena K. Capellini, Andrea C. Celotto, Caroline F. Baldo, Vania C. Olivon, Fernanda Viaro, Alfredo J. Rodrigues, Paulo R.B. Evora

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

The vascular manifestations associated with diabetes mellitus (DM) result from the dysfunction of several vascular physiology components mainly involving the endothelium, vascular smooth muscle and platelets. It is also known that hyperglycemia-induced oxidative stress plays a role in the development of this dysfunction. This review considers the basic physiology of the endothelium, especially related to the synthesis and function of nitric oxide. We also discuss the pathophysiology of vascular disease associated with DM. This includes the role of hyperglycemia in the induction of oxidative stress and the role of advanced glycation end-products. We also consider therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)526-544
Number of pages19
JournalCurrent Vascular Pharmacology
Volume8
Issue number4
DOIs
StatePublished - Jul 23 2010

Keywords

  • Advanced glycation end-products
  • Antioxidants
  • Diabetes
  • Endothelium
  • Nitric oxide
  • Oxidative stress
  • Vascular dysfunction

Fingerprint Dive into the research topics of 'Diabetes and vascular disease: Basic concepts of nitric oxide physiology, endothelial dysfunction, oxidative stress and therapeutic possibilities'. Together they form a unique fingerprint.

  • Cite this