Devices for esophageal function testing

Rahul Pannala, Kumar Krishnan, Rabindra R. Watson, Marcelo F. Vela, Barham K. Abu Dayyeh, Amit Bhatt, Manoop S. Bhutani, Juan Carlos Bucobo, Vinay Chandrasekhara, Andrew P. Copland, Pichamol Jirapinyo, Nikhil A. Kumta, Ryan J. Law, John T. Maple, Joshua Melson, Mansour A. Parsi, Erik F. Rahimi, Monica Saumoy, Amrita Sethi, Guru TrikudanathanArvind J. Trindade, Julie Yang, David R. Lichtenstein

Research output: Contribution to journalArticlepeer-review

Abstract

Background and Aims: Esophageal function testing is an integral component of the evaluation of refractory GERD and esophageal motility disorders. This review summarizes the current technologies available for esophageal function testing, including the functional luminal imaging probe (FLIP), high-resolution esophageal manometry (HRM), and multichannel intraluminal impedance (MII) and pH monitoring. Methods: We performed a MEDLINE, PubMed, and MAUDE database literature search to identify pertinent clinical studies through March 2021 using the following key words: esophageal manometry, HRM, esophageal impedance, FLIP, MII, and esophageal pH testing. Technical data were gathered from traditional and web-based publications, proprietary publications, and informal communications with pertinent vendors. The report was drafted, reviewed, and edited by the American Society for Gastrointestinal Endoscopy Technology Committee and approved by the Governing Board of the American Society for Gastrointestinal Endoscopy. Results: FLIP is a high-resolution impedance planimetry system used for pressure and dimension measurement in the esophagus, pylorus, and anal sphincter. FLIP provides complementary information to HRM for esophageal motility disorders, especially achalasia. The Chicago classification, based on HRM data, is a widely adopted algorithmic scheme used to diagnose esophageal motility disorders. MII detects intraluminal bolus movement and, combined with pH measurement or manometry, provides information on acid and non-acid gastroesophageal reflux and bolus transit in patients with refractory GERD and for preoperative evaluation for anti-reflux procedures. Conclusions: Esophageal function testing techniques (FLIP, HRM, and MII-pH) have diagnostic and prognostic value in the evaluation of esophageal motility disorders and refractory GERD. Newer technologies and classification systems have enabled an increased understanding of these diseases.

Original languageEnglish (US)
Pages (from-to)1-20
Number of pages20
JournalVideoGIE
Volume7
Issue number1
DOIs
StatePublished - Jan 2022

Bibliographical note

Funding Information:
The ASGE Technology committee is grateful to Dr Michael Crowell, Mayo Clinic Arizona, for providing guidance on this manuscript, as well as Drs Glenn Littenberg, Felix Leung, and Jenifer Lightdale for their review of this document. Disclosure: Dr Pannala is a consultant for HCL Technologies; has received travel compensation and food and beverage from Boston Scientific Corporation; has received food and beverage from Apollo Endosurgery US, Inc.; and is on the scientific advisory board for Nestle Health Sciences. Dr Krishnan is a consultant for Olympus Corporation of the Americas and Medtronic; has received travel compensation and food and beverage from Olympus Corporation of the Americas; and has received food and beverage from Boston Scientific Corporation. Dr Watson is a consultant and speaker for and has received travel compensation and food and beverage from Apollo Endosurgery US Inc and Boston Scientific Corporation; is a consultant for Neptune Medical Inc.; and has received food and beverage from Covidien LP, ERBE USA Inc, and Braintree Laboratories, Inc. Dr Vela is a consultant for Medtronic USA, Inc. Dr Abu Dayyeh is a consultant for Metamodix, BFKW, Endogenex, Hemostasis, and Boston Scientific Corporation; is a consultant and has received research support from Medtronic; has received research support from Apollo Endosurgery, USGI, Spatz Medical, GI Dynamics, Cairn Diagnostics, Endogastric Solutions Inc., and Aspire Bariatrics.; is a speaker for Johnson and Johnson, Endogastric Solutions Inc., and Olympus Corporation of the Americas; has received travel compensation and food and beverage from Olympus Corporation of the Americas and Endogastric Solutions, Inc.; and has received food and beverage from Boston Scientific Corporation, Covidien LP, Apollo Endosurgery US Inc, and Medrobotics Inc. Dr Bhatt is a consultant and speaker for Boston Scientific Corporation, Eleview, and Olympus Corporation of the Americas; is a consultant and speaker for and receives royalties from Medtronics; is a consultant for and has received food and beverage from Lumendi LLC; has a patent for a commercial device licensed to Medtronic; and has received food and beverage from Covidien LP, Boston Scientific Corporation, Olympus America Inc., and Shionogi Inc. Dr Bhutani has received research grants from Silenseed Inc., Galera Inc, Oncosil Inc., Nanobiotix, and Augmenix Inc.; has received food and beverage from Augmenix Inc., Conmed Corporation, Boston Scientific Corporation, and Olympus Corporation of the Americas; and has received travel compensation from Augmenix Inc. Dr Bucobo is a consultant for and has received travel compensation and food and beverage from Cook Medical LLC; has received travel compensation and food and beverage from Olympus Corporation of the Americas; and has received food and beverage from Boston Scientific Corporation, AbbVie, Inc., Janssen Biotech, Inc., STERIS CORPORATION, Ferring Pharmaceuticals Inc., Takeda Pharmaceuticals U.S.A., Inc., Endogastric Solutions, Inc., Merck Sharp & Dohme Corporation, Dova Pharmaceuticals, PFIZER INC., and Allergan Inc. Dr Chandrasekhara is a consultant for Covidien LP; is on the advisory board for Interpace Diagnostics; is a shareholder in Nevakar, Inc.; and has received food and beverage from Olympus America Inc. and Boston Scientific Corporation. Dr Copland has received education compensation from Salix Pharmaceauticals, Ltd. Dr Jirapinyo is a consultant for Endogastric Solutions, and Lumendi; is a consultant for and has received research support from GI Dynamics; has received research support from Apollo Endosurgery and Fractyl; has received travel compensation and food and beverage from Boston Scientific Corporation; and has received travel compensation from Olympus Corporation of the Americas. Dr Kumta is a consultant for and has received travel compensation and food and beverage from Boston Scientific Corporation, Gyrus ACMI, Inc., Olympus Corporation of the Americas, and Apollo Endosurgery US Inc.; and has received food and beverage from FIJUFILM Medical Systems USA, Inc., STERIS CORPORATION, ERBE USA Inc., Endogastric Solutions, and CONMED Corporation. Dr Law is a consultant for and has received travel compensation and food and beverage from Olympus America Inc.; is a consultant for Medtronic; and has received food and beverage from Boston Scientific Corporation. Dr Maple has received food and beverage from Covidien LP, Olympus America Inc., and Boston Scientific Corporation. Dr Melson received an investigator-initiated grant from and has received food and beverage from Boston Scientific Corporation; has received food and beverage from Cook Medical LLC; is a consultant for Geneoscopy; and has stock options with Virgo Imaging. Dr Parsi has received travel compensation and food and beverage from Olympus Corporation of the Americas; and has received food and beverage from CONMED Corporation, Salix Pharmaceuticals, AbbVie, Inc., Shionogi Inc., Shire North American Group Inc., and Boston Scientific Corporation. Dr Rahimi has received food and beverage from AbbVie, Inc., Boston Scientific Corporation, and Covidien LP. Dr Saumoy has received food and beverage from Boston Scientific Corporation, Ethicon US, LLC, Allergan Inc., and AbbVie, Inc. Dr Sethi is a consultant for Boston Scientific Corporation, Fujifilm, Medtronic, Micro-Tech, Intuitive Surgical, and Olympus Corporation of the Americas; has received travel compensation and food and beverage from ERBE USA, Inc., Covidien LP, and Cook Medical LLC; and has received food and beverage from Lumendi. Dr Trikudanathan is a consultant for and has received travel compensation and food and beverage from Boston Scientific Corporation; and has received food and beverage from Cook Medical LLC. Dr Trindade is a consultant for and has received food and beverage from Olympus Corporation of the Americas; is a consultant for and has received travel compensation and food and beverage from PENTAX of America, Inc.; has consulted for and received travel compensation and food and beverage from Gyrus ACMI, Inc.; has received food and beverage from Boston Scientific Corporation; and has a research grant from NinePoint Medical, Inc. Dr Yang is a consultant for and has received travel compensation and food and beverage from Olympus Corporation of the Americas; is a consultant for and has received food and beverage from Cook Medical LLC; and has received food and beverage from US Endoscopy, Boston Scientific Corporation, CONMED Corporation, Salix Pharmaceuticals, and AbbVie, Inc. Dr Lichtenstein is a consultant for and has received education compensation, travel compensation, and food and beverage from Olympus Corporation of the Americas; is a consultant for Iterative Scopes, CONMED Corporation, AMBU; and is a consultant and has received food and beverage from Boston Scientific Corporation.

Funding Information:
Disclosure: Dr Pannala is a consultant for HCL Technologies; has received travel compensation and food and beverage from Boston Scientific Corporation; has received food and beverage from Apollo Endosurgery US, Inc.; and is on the scientific advisory board for Nestle Health Sciences. Dr Krishnan is a consultant for Olympus Corporation of the Americas and Medtronic; has received travel compensation and food and beverage from Olympus Corporation of the Americas; and has received food and beverage from Boston Scientific Corporation. Dr Watson is a consultant and speaker for and has received travel compensation and food and beverage from Apollo Endosurgery US Inc and Boston Scientific Corporation; is a consultant for Neptune Medical Inc.; and has received food and beverage from Covidien LP, ERBE USA Inc, and Braintree Laboratories, Inc. Dr Vela is a consultant for Medtronic USA, Inc. Dr Abu Dayyeh is a consultant for Metamodix, BFKW, Endogenex, Hemostasis, and Boston Scientific Corporation; is a consultant and has received research support from Medtronic; has received research support from Apollo Endosurgery, USGI, Spatz Medical, GI Dynamics, Cairn Diagnostics, Endogastric Solutions Inc., and Aspire Bariatrics.; is a speaker for Johnson and Johnson, Endogastric Solutions Inc., and Olympus Corporation of the Americas; has received travel compensation and food and beverage from Olympus Corporation of the Americas and Endogastric Solutions, Inc.; and has received food and beverage from Boston Scientific Corporation, Covidien LP, Apollo Endosurgery US Inc, and Medrobotics Inc. Dr Bhatt is a consultant and speaker for Boston Scientific Corporation, Eleview, and Olympus Corporation of the Americas; is a consultant and speaker for and receives royalties from Medtronics; is a consultant for and has received food and beverage from Lumendi LLC; has a patent for a commercial device licensed to Medtronic; and has received food and beverage from Covidien LP, Boston Scientific Corporation, Olympus America Inc., and Shionogi Inc. Dr Bhutani has received research grants from Silenseed Inc., Galera Inc, Oncosil Inc., Nanobiotix, and Augmenix Inc.; has received food and beverage from Augmenix Inc., Conmed Corporation, Boston Scientific Corporation, and Olympus Corporation of the Americas; and has received travel compensation from Augmenix Inc. Dr Bucobo is a consultant for and has received travel compensation and food and beverage from Cook Medical LLC; has received travel compensation and food and beverage from Olympus Corporation of the Americas; and has received food and beverage from Boston Scientific Corporation, AbbVie, Inc., Janssen Biotech, Inc., STERIS CORPORATION, Ferring Pharmaceuticals Inc., Takeda Pharmaceuticals U.S.A., Inc., Endogastric Solutions, Inc., Merck Sharp & Dohme Corporation, Dova Pharmaceuticals, PFIZER INC., and Allergan Inc. Dr Chandrasekhara is a consultant for Covidien LP; is on the advisory board for Interpace Diagnostics; is a shareholder in Nevakar, Inc.; and has received food and beverage from Olympus America Inc. and Boston Scientific Corporation. Dr Copland has received education compensation from Salix Pharmaceauticals, Ltd. Dr Jirapinyo is a consultant for Endogastric Solutions, and Lumendi; is a consultant for and has received research support from GI Dynamics; has received research support from Apollo Endosurgery and Fractyl; has received travel compensation and food and beverage from Boston Scientific Corporation; and has received travel compensation from Olympus Corporation of the Americas. Dr Kumta is a consultant for and has received travel compensation and food and beverage from Boston Scientific Corporation, Gyrus ACMI, Inc., Olympus Corporation of the Americas, and Apollo Endosurgery US Inc.; and has received food and beverage from FIJUFILM Medical Systems USA, Inc., STERIS CORPORATION, ERBE USA Inc., Endogastric Solutions, and CONMED Corporation. Dr Law is a consultant for and has received travel compensation and food and beverage from Olympus America Inc.; is a consultant for Medtronic; and has received food and beverage from Boston Scientific Corporation. Dr Maple has received food and beverage from Covidien LP, Olympus America Inc., and Boston Scientific Corporation. Dr Melson received an investigator-initiated grant from and has received food and beverage from Boston Scientific Corporation; has received food and beverage from Cook Medical LLC; is a consultant for Geneoscopy; and has stock options with Virgo Imaging. Dr Parsi has received travel compensation and food and beverage from Olympus Corporation of the Americas; and has received food and beverage from CONMED Corporation, Salix Pharmaceuticals, AbbVie, Inc., Shionogi Inc., Shire North American Group Inc., and Boston Scientific Corporation. Dr Rahimi has received food and beverage from AbbVie, Inc., Boston Scientific Corporation, and Covidien LP. Dr Saumoy has received food and beverage from Boston Scientific Corporation, Ethicon US, LLC, Allergan Inc., and AbbVie, Inc. Dr Sethi is a consultant for Boston Scientific Corporation, Fujifilm, Medtronic, Micro-Tech, Intuitive Surgical, and Olympus Corporation of the Americas; has received travel compensation and food and beverage from ERBE USA, Inc., Covidien LP, and Cook Medical LLC; and has received food and beverage from Lumendi. Dr Trikudanathan is a consultant for and has received travel compensation and food and beverage from Boston Scientific Corporation; and has received food and beverage from Cook Medical LLC. Dr Trindade is a consultant for and has received food and beverage from Olympus Corporation of the Americas; is a consultant for and has received travel compensation and food and beverage from PENTAX of America, Inc.; has consulted for and received travel compensation and food and beverage from Gyrus ACMI, Inc.; has received food and beverage from Boston Scientific Corporation; and has a research grant from NinePoint Medical, Inc. Dr Yang is a consultant for and has received travel compensation and food and beverage from Olympus Corporation of the Americas; is a consultant for and has received food and beverage from Cook Medical LLC; and has received food and beverage from US Endoscopy, Boston Scientific Corporation, CONMED Corporation, Salix Pharmaceuticals, and AbbVie, Inc. Dr Lichtenstein is a consultant for and has received education compensation, travel compensation, and food and beverage from Olympus Corporation of the Americas; is a consultant for Iterative Scopes, CONMED Corporation, AMBU; and is a consultant and has received food and beverage from Boston Scientific Corporation.

Publisher Copyright:
© 2022 American Society for Gastrointestinal Endoscopy

Keywords

  • Esophageal pH Monitoring
  • Esophagus/diagnostic imaging
  • Humans
  • Manometry

PubMed: MeSH publication types

  • Practice Guideline

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