Developmental plasticity of NMDA receptors at the calyx of Held synapse

Maria Gurma, Yi Mei Yang, Lu Yang Wang

Research output: Contribution to journalReview articlepeer-review

Abstract

Excitatory synaptic transmission is largely mediated by glutamate receptors in central synapses, such as the calyx of Held synapse in the auditory brainstem. This synapse is best known for undergoing extensive morphological and functional changes throughout early development and thereby has served as a prominent model system to study presynaptic mechanisms of neurotransmitter release. However, the pivotal roles of N-methyl-d-aspartate receptors (NMDARs) in gating acute forms of activity-dependent, persistent plasticity in vitro and chronic developmental remodeling in vivo are hardly noted. This article will provide a retrospective review of key experimental evidence to conceptualize the impact of a transient abundance of NMDARs during the early postnatal stage on the functionality of fast-spiking central synapses while raising a series of outstanding questions that are of general significance for understanding the developing brain in health and diseases. This article is part of the special Issue on "Glutamate Receptors - NMDA receptors".

Original languageEnglish (US)
Article number108697
JournalNeuropharmacology
Volume196
DOIs
StatePublished - Sep 15 2021
Externally publishedYes

Bibliographical note

Funding Information:
The authors' work has been supported by grants from Canadian Institutes of Health Research , Natural Science and Engineering Research Council and Canada Research Chair Program.

Publisher Copyright:
© 2021 Elsevier Ltd

Keywords

  • AMPA receptors
  • Activity-Dependent synaptic plasticity
  • Developmental plasticity
  • NMDA receptors
  • The calyx of held synapse
  • mGluRs

PubMed: MeSH publication types

  • Journal Article
  • Review
  • Research Support, Non-U.S. Gov't

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