Developmental pathogenicity of 4-repeat human tau is lost with the P301L mutation in genetically matched tau-transgenic mice

Keyphrases

• Pathogenicity 100%
• Human tau 100%
• P301L mutation 100%
• Tau Transgenic Mouse 100%
• Tauopathy 40%
• P301L 30%
• Cognitive Impairment 20%
• Transgenic Mouse Model 20%
• Overexpression 20%
• Molecular Phenotype 20%
• Postnatal Development 20%
• Cognitive Phenotype 20%
• Hyperphosphorylation 20%
• Aging 10%
• Transgenic Mice 10%
• Transgenic 10%
• Overexpressing 10%
• Disease-modifying Therapy 10%
• Microtubules 10%
• Expression Level 10%
• Biological Role 10%
• Dysregulated 10%
• Mitochondrial Dynamics 10%
• Cellular Processes 10%
• Neurodegenerative Diseases 10%
• Aged Mice 10%
• Female Mice 10%
• Male Mice 10%
• Microtubule Binding 10%
• Protein Stability 10%
• Microtubule-associated Protein 10%
• Endogenous Genes 10%
• Tau Protein 10%
• Disease-related Proteins 10%
• Transgenic Lines 10%
• Tau Isoforms 10%
• Isoform Expression 10%
• Underlining 10%
• Tau mutation 10%
• Mitochondrial Abnormalities 10%
• Stronger Binding 10%
• Abnormal Dynamics 10%
• Tau Hyperphosphorylation 10%
• Elevated Protein 10%
• Pathogenic Properties 10%

Neuroscience

• Tauopathy 100%
• Hyperphosphorylation 75%
• Cognitive Disorders 50%
• Microtubules 50%
• In Vivo 25%
• Neurodegenerative Disorder 25%
• Tau Protein 25%
• Promoter Region 25%
• Microtubule Associated Protein 25%
• Protein Stability 25%
• Mitochondrial Dynamics 25%
• Transgene 25%

Biochemistry, Genetics and Molecular Biology

• Tau 100%
• Transgenic Mouse 100%
• Hyperphosphorylation 17%
• Mouse Model 11%
• Transgenics 11%
• Postnatal Development 11%
• Dynamics 5%
• Isoform 5%
• Transgene 5%
• Microtubule-Associated Protein 5%
• Mitochondrial Dynamics 5%
• Promoter Region 5%
• Protein Stability 5%
• Tau Protein 5%