Developmental Maturation: Drosophila AstA Signaling Provides a Kiss to Grow Up

Xueyang Pan; Michael B O'Connor

doi:10.1016/j.cub.2019.01.040

Developmental Maturation: Drosophila AstA Signaling Provides a Kiss to Grow Up

Xueyang Pan
, Michael B O'Connor

Genetics, Cell Biology and Development (CBS)

Research output: Contribution to journal › Short survey › peer-review

11 Scopus citations

Abstract

Insect metamorphosis and mammalian puberty exhibit similar design principles, but the conservation of molecular components has not been documented. A new study demonstrates that the insect neuropeptide allatostatin A and its receptor AstAR1 activate a neuroendocrine signaling cascade that initiates metamorphosis, similar to the way in which their mammalian orthologs Kisspeptin and KISS1R induce puberty. Insect metamorphosis and mammalian puberty exhibit similar design principles, but the conservation of molecular components has not been documented. A new study demonstrates that the insect neuropeptide allatostatin A and its receptor AstAR1 activate a neuroendocrine signaling cascade that initiates metamorphosis, similar to the way in which their mammalian orthologs Kisspeptin and KISS1R induce puberty.

Original language	English (US)
Pages (from-to)	R161-R164
Journal	Current Biology
Volume	29
Issue number	5
DOIs	https://doi.org/10.1016/j.cub.2019.01.040
State	Published - Mar 4 2019

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Ltd

Keywords

Animals
Biological Evolution
Drosophila
Kisspeptins
Neurosecretory Systems
Receptors, Kisspeptin-1
Signal Transduction

PubMed: MeSH publication types

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Journal Article

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10.1016/j.cub.2019.01.040

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title = "Developmental Maturation: Drosophila AstA Signaling Provides a Kiss to Grow Up",

abstract = "Insect metamorphosis and mammalian puberty exhibit similar design principles, but the conservation of molecular components has not been documented. A new study demonstrates that the insect neuropeptide allatostatin A and its receptor AstAR1 activate a neuroendocrine signaling cascade that initiates metamorphosis, similar to the way in which their mammalian orthologs Kisspeptin and KISS1R induce puberty. Insect metamorphosis and mammalian puberty exhibit similar design principles, but the conservation of molecular components has not been documented. A new study demonstrates that the insect neuropeptide allatostatin A and its receptor AstAR1 activate a neuroendocrine signaling cascade that initiates metamorphosis, similar to the way in which their mammalian orthologs Kisspeptin and KISS1R induce puberty.",

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AU - O'Connor, Michael B

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AB - Insect metamorphosis and mammalian puberty exhibit similar design principles, but the conservation of molecular components has not been documented. A new study demonstrates that the insect neuropeptide allatostatin A and its receptor AstAR1 activate a neuroendocrine signaling cascade that initiates metamorphosis, similar to the way in which their mammalian orthologs Kisspeptin and KISS1R induce puberty. Insect metamorphosis and mammalian puberty exhibit similar design principles, but the conservation of molecular components has not been documented. A new study demonstrates that the insect neuropeptide allatostatin A and its receptor AstAR1 activate a neuroendocrine signaling cascade that initiates metamorphosis, similar to the way in which their mammalian orthologs Kisspeptin and KISS1R induce puberty.

KW - Animals

KW - Biological Evolution

KW - Drosophila

KW - Kisspeptins

KW - Neurosecretory Systems

KW - Receptors, Kisspeptin-1

KW - Signal Transduction

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Developmental Maturation: Drosophila AstA Signaling Provides a Kiss to Grow Up

Abstract

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Keywords

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