Developmental Checkpoints and Feedback Circuits Time Insect Maturation

Kim F. Rewitz, Naoki Yamanaka, Michael B O'Connor

Research output: Chapter in Book/Report/Conference proceedingChapter

77 Scopus citations

Abstract

The transition from juvenile to adult is a fundamental process that allows animals to allocate resource toward reproduction after completing a certain amount of growth. In insects, growth to a species-specific target size induces pulses of the steroid hormone ecdysone that triggers metamorphosis and reproductive maturation. The past few years have seen significant progress in understanding the interplay of mechanisms that coordinate timing of ecdysone production and release. These studies show that the neuroendocrine system monitors complex size-related and nutritional signals, as well as external cues, to time production and release of ecdysone. Based on results discussed here, we suggest that developmental progression to adulthood is controlled by checkpoints that regulate the genetic timing program enabling it to adapt to different environmental conditions. These checkpoints utilize a number of signaling pathways to modulate ecdysone production in the prothoracic gland. Release of ecdysone activates an autonomous cascade of both feedforward and feedback signals that determine the duration of the ecdysone pulse at each developmental transitions. Conservation of the genetic mechanisms that coordinate the juvenile-adult transition suggests that insights from the fruit fly Drosophila will provide a framework for future investigation of developmental timing in metazoans.

Original languageEnglish (US)
Title of host publicationCurrent Topics in Developmental Biology
PublisherAcademic Press Inc.
Pages1-33
Number of pages33
DOIs
StatePublished - 2013

Publication series

NameCurrent Topics in Developmental Biology
Volume103
ISSN (Print)0070-2153

Bibliographical note

Funding Information:
K.F.R. is supported by grant 11-105446 from the Danish Council for Independent Research, Natural Sciences. N.Y. is supported by NIH grant K99 HD073239 and M.B.O by NIH R01 GM093301.

Keywords

  • Developmental checkpoints
  • Ecdysone
  • Insulin signaling
  • PTTH
  • Prothoracic gland

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