Developmental changes in thymidine kinase, DNA, and fat cellularity in Zucker rats.

M. P. Cleary, J. A. Brasel, M. R. Greenwood

Research output: Contribution to journalArticle

Abstract

Thymidine kinase activity and the pattern of DNA accretion in the genetically obese Zucker rat (fafa) were shown to develop in a manner fundamentally different from that of the lean rat. In normal lean Zucker rats, fat cell size and number, thymidine kinase activity, total DNA, and DNA in lipid-filled and nonlipid-filled tissue changed as previously reported for the normally growing lean Sprague-Dawley rat. In the epididymal depot of the developing obese rat, the progressive obesity is characterized by marked early enlargement of fat cell size, elevated thymidine kinase activity until 273 days of age, increased rate of total tissue DNA accretion until 182 days of age, and fat cell hyperplasia that becomes manifest after an apparent "peak" cell size is reached at 98 days of age.

Original languageEnglish (US)
JournalThe American journal of physiology
Volume236
Issue number5
StatePublished - May 1 1979

Fingerprint

Zucker Rats
Thymidine Kinase
Fats
Cell Size
Adipocytes
DNA
Hyperplasia
Sprague Dawley Rats
Obesity
Cell Count
Lipids

Cite this

Developmental changes in thymidine kinase, DNA, and fat cellularity in Zucker rats. / Cleary, M. P.; Brasel, J. A.; Greenwood, M. R.

In: The American journal of physiology, Vol. 236, No. 5, 01.05.1979.

Research output: Contribution to journalArticle

Cleary, M. P. ; Brasel, J. A. ; Greenwood, M. R. / Developmental changes in thymidine kinase, DNA, and fat cellularity in Zucker rats. In: The American journal of physiology. 1979 ; Vol. 236, No. 5.
@article{f659cf245d5b40848f0a52bd44003908,
title = "Developmental changes in thymidine kinase, DNA, and fat cellularity in Zucker rats.",
abstract = "Thymidine kinase activity and the pattern of DNA accretion in the genetically obese Zucker rat (fafa) were shown to develop in a manner fundamentally different from that of the lean rat. In normal lean Zucker rats, fat cell size and number, thymidine kinase activity, total DNA, and DNA in lipid-filled and nonlipid-filled tissue changed as previously reported for the normally growing lean Sprague-Dawley rat. In the epididymal depot of the developing obese rat, the progressive obesity is characterized by marked early enlargement of fat cell size, elevated thymidine kinase activity until 273 days of age, increased rate of total tissue DNA accretion until 182 days of age, and fat cell hyperplasia that becomes manifest after an apparent {"}peak{"} cell size is reached at 98 days of age.",
author = "Cleary, {M. P.} and Brasel, {J. A.} and Greenwood, {M. R.}",
year = "1979",
month = "5",
day = "1",
language = "English (US)",
volume = "236",
journal = "American Journal of Physiology - Cell Physiology",
issn = "0363-6143",
publisher = "American Physiological Society",
number = "5",

}

TY - JOUR

T1 - Developmental changes in thymidine kinase, DNA, and fat cellularity in Zucker rats.

AU - Cleary, M. P.

AU - Brasel, J. A.

AU - Greenwood, M. R.

PY - 1979/5/1

Y1 - 1979/5/1

N2 - Thymidine kinase activity and the pattern of DNA accretion in the genetically obese Zucker rat (fafa) were shown to develop in a manner fundamentally different from that of the lean rat. In normal lean Zucker rats, fat cell size and number, thymidine kinase activity, total DNA, and DNA in lipid-filled and nonlipid-filled tissue changed as previously reported for the normally growing lean Sprague-Dawley rat. In the epididymal depot of the developing obese rat, the progressive obesity is characterized by marked early enlargement of fat cell size, elevated thymidine kinase activity until 273 days of age, increased rate of total tissue DNA accretion until 182 days of age, and fat cell hyperplasia that becomes manifest after an apparent "peak" cell size is reached at 98 days of age.

AB - Thymidine kinase activity and the pattern of DNA accretion in the genetically obese Zucker rat (fafa) were shown to develop in a manner fundamentally different from that of the lean rat. In normal lean Zucker rats, fat cell size and number, thymidine kinase activity, total DNA, and DNA in lipid-filled and nonlipid-filled tissue changed as previously reported for the normally growing lean Sprague-Dawley rat. In the epididymal depot of the developing obese rat, the progressive obesity is characterized by marked early enlargement of fat cell size, elevated thymidine kinase activity until 273 days of age, increased rate of total tissue DNA accretion until 182 days of age, and fat cell hyperplasia that becomes manifest after an apparent "peak" cell size is reached at 98 days of age.

UR - http://www.scopus.com/inward/record.url?scp=0018472791&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018472791&partnerID=8YFLogxK

M3 - Article

VL - 236

JO - American Journal of Physiology - Cell Physiology

JF - American Journal of Physiology - Cell Physiology

SN - 0363-6143

IS - 5

ER -