The 29 Mr x 10-3 IGFBP was significantly elevated (P < 0.01) in IUGR piglets at 90 days fetally and at birth. Developmentally, 29 Mr x 10-3 IGFBP levels were higher fetally and at birth than at 21 and 49 days of age (P < 0.05). At 90 days fetally, hepatic IGFBP-3 mRNA levels were very high, while circulating levels of IGFBP-3 were extremely low whereas postnatally, hepatic IGFBP-3 mRNA and serum IGFBP-3 levels were parallel. This study provides new information concerning the developmental expression of IGFBP-3 and the relationship between serum levels of the 29 Mr x 10-3 IGFBP and IUGR in swine.
|Original language||English (US)|
|Number of pages||11|
|Journal||Comparative Biochemistry and Physiology -- Part B: Biochemistry and|
|State||Published - Jul 1994|
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- IUGR swine