Developmental changes in serum IGF-1 and IGFBP levels and liver IGFBP-3 mRNA expression in intrauterine growth-retarded and control swine

Kimberly A. Kampman; Timothy G. Ramsay; Michael E. White

doi:10.1016/0305-0491(94)90085-X

Developmental changes in serum IGF-1 and IGFBP levels and liver IGFBP-3 mRNA expression in intrauterine growth-retarded and control swine

Kimberly A. Kampman, Timothy G. Ramsay, Michael E. White

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Abstract

The 29 M_r x 10^-3 IGFBP was significantly elevated (P < 0.01) in IUGR piglets at 90 days fetally and at birth. Developmentally, 29 M_r x 10^-3 IGFBP levels were higher fetally and at birth than at 21 and 49 days of age (P < 0.05). At 90 days fetally, hepatic IGFBP-3 mRNA levels were very high, while circulating levels of IGFBP-3 were extremely low whereas postnatally, hepatic IGFBP-3 mRNA and serum IGFBP-3 levels were parallel. This study provides new information concerning the developmental expression of IGFBP-3 and the relationship between serum levels of the 29 M_r x 10^-3 IGFBP and IUGR in swine.

Original language	English (US)
Pages (from-to)	337-347
Number of pages	11
Journal	Comparative Biochemistry and Physiology -- Part B: Biochemistry and
Volume	108
Issue number	3
DOIs	https://doi.org/10.1016/0305-0491(94)90085-X
State	Published - Jul 1994

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Copyright 2014 Elsevier B.V., All rights reserved.

Keywords

IGF
IGFBPS
IUGR swine

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10.1016/0305-0491(94)90085-X

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Developmental changes in serum IGF-1 and IGFBP levels and liver IGFBP-3 mRNA expression in intrauterine growth-retarded and control swine. / Kampman, Kimberly A.; Ramsay, Timothy G.; White, Michael E.
In: Comparative Biochemistry and Physiology -- Part B: Biochemistry and, Vol. 108, No. 3, 07.1994, p. 337-347.

Research output: Contribution to journal › Article › peer-review

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abstract = "The 29 Mr x 10-3 IGFBP was significantly elevated (P < 0.01) in IUGR piglets at 90 days fetally and at birth. Developmentally, 29 Mr x 10-3 IGFBP levels were higher fetally and at birth than at 21 and 49 days of age (P < 0.05). At 90 days fetally, hepatic IGFBP-3 mRNA levels were very high, while circulating levels of IGFBP-3 were extremely low whereas postnatally, hepatic IGFBP-3 mRNA and serum IGFBP-3 levels were parallel. This study provides new information concerning the developmental expression of IGFBP-3 and the relationship between serum levels of the 29 Mr x 10-3 IGFBP and IUGR in swine.",

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N2 - The 29 Mr x 10-3 IGFBP was significantly elevated (P < 0.01) in IUGR piglets at 90 days fetally and at birth. Developmentally, 29 Mr x 10-3 IGFBP levels were higher fetally and at birth than at 21 and 49 days of age (P < 0.05). At 90 days fetally, hepatic IGFBP-3 mRNA levels were very high, while circulating levels of IGFBP-3 were extremely low whereas postnatally, hepatic IGFBP-3 mRNA and serum IGFBP-3 levels were parallel. This study provides new information concerning the developmental expression of IGFBP-3 and the relationship between serum levels of the 29 Mr x 10-3 IGFBP and IUGR in swine.

AB - The 29 Mr x 10-3 IGFBP was significantly elevated (P < 0.01) in IUGR piglets at 90 days fetally and at birth. Developmentally, 29 Mr x 10-3 IGFBP levels were higher fetally and at birth than at 21 and 49 days of age (P < 0.05). At 90 days fetally, hepatic IGFBP-3 mRNA levels were very high, while circulating levels of IGFBP-3 were extremely low whereas postnatally, hepatic IGFBP-3 mRNA and serum IGFBP-3 levels were parallel. This study provides new information concerning the developmental expression of IGFBP-3 and the relationship between serum levels of the 29 Mr x 10-3 IGFBP and IUGR in swine.

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Developmental changes in serum IGF-1 and IGFBP levels and liver IGFBP-3 mRNA expression in intrauterine growth-retarded and control swine

Abstract

Bibliographical note

Keywords

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