Development of white matter fiber covariance networks supports executive function in youth

Joëlle Bagautdinova, Josiane Bourque, Valerie J. Sydnor, Matthew Cieslak, Aaron F. Alexander-Bloch, Maxwell A. Bertolero, Philip A. Cook, Raquel E. Gur, Ruben C. Gur, Fengling Hu, Bart Larsen, Tyler M. Moore, Hamsanandini Radhakrishnan, David R. Roalf, Russel T. Shinohara, Tinashe M. Tapera, Chenying Zhao, Aristeidis Sotiras, Christos Davatzikos, Theodore D. Satterthwaite

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

During adolescence, the brain undergoes extensive changes in white matter structure that support cognition. Data-driven approaches applied to cortical surface properties have led the field to understand brain development as a spatially and temporally coordinated mechanism that follows hierarchically organized gradients of change. Although white matter development also appears asynchronous, previous studies have relied largely on anatomical tract-based atlases, precluding a direct assessment of how white matter structure is spatially and temporally coordinated. Harnessing advances in diffusion modeling and machine learning, we identified 14 data-driven patterns of covarying white matter structure in a large sample of youth. Fiber covariance networks aligned with known major tracts, while also capturing distinct patterns of spatial covariance across distributed white matter locations. Most networks showed age-related increases in fiber network properties, which were also related to developmental changes in executive function. This study delineates data-driven patterns of white matter development that support cognition.

Original languageEnglish (US)
Article number113487
JournalCell reports
Volume42
Issue number12
DOIs
StatePublished - Dec 26 2023
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2023 The Author(s)

Keywords

  • CP: Neuroscience
  • development
  • diffusion-weighted imaging
  • executive function
  • fixel-based analysis
  • network
  • non-negative matrix factorization
  • youth

PubMed: MeSH publication types

  • Journal Article

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