Development of tolerance to the side effects of primidone

Ilo E Leppik; James C Cloyd; Kenneth Miller

doi:10.1097/00007691-198406000-00010

Development of tolerance to the side effects of primidone

Ilo E Leppik, James C Cloyd, Kenneth Miller

Experimental and Clinical Pharmacology

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18 Scopus citations

Abstract

Side effects and antiepileptic drug levels were measured during initiation of and chronic treatment with primidone (PRM). A significant change in the toxicity/serum level ratio was observed 6 h after the initial PRM dose. The amount of toxicity manifested by patients receiving PRM as their initial antiepileptic drug was not different from that of those patients previously treated with phenytoin (PHT) or carbamazepine (CBZ). These findings indicate rapid development of functional tolerance to side effects of PRM, which is not altered by previous exposure to PHT or CBZ. Phenobarbital pretreatment appears to produce cross-tolerance to the effects of PRM.

Original language	English (US)
Pages (from-to)	189-191
Number of pages	3
Journal	Therapeutic drug monitoring
Volume	6
Issue number	2
DOIs	https://doi.org/10.1097/00007691-198406000-00010
State	Published - Jun 1984

Bibliographical note

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Copyright 2017 Elsevier B.V., All rights reserved.

Keywords

Antiepileptic drug
Primidone
Side effects
Tolerance
Toxicity

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10.1097/00007691-198406000-00010

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abstract = "Side effects and antiepileptic drug levels were measured during initiation of and chronic treatment with primidone (PRM). A significant change in the toxicity/serum level ratio was observed 6 h after the initial PRM dose. The amount of toxicity manifested by patients receiving PRM as their initial antiepileptic drug was not different from that of those patients previously treated with phenytoin (PHT) or carbamazepine (CBZ). These findings indicate rapid development of functional tolerance to side effects of PRM, which is not altered by previous exposure to PHT or CBZ. Phenobarbital pretreatment appears to produce cross-tolerance to the effects of PRM.",

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AU - Leppik, Ilo E

AU - Cloyd, James C

AU - Miller, Kenneth

PY - 1984/6

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AB - Side effects and antiepileptic drug levels were measured during initiation of and chronic treatment with primidone (PRM). A significant change in the toxicity/serum level ratio was observed 6 h after the initial PRM dose. The amount of toxicity manifested by patients receiving PRM as their initial antiepileptic drug was not different from that of those patients previously treated with phenytoin (PHT) or carbamazepine (CBZ). These findings indicate rapid development of functional tolerance to side effects of PRM, which is not altered by previous exposure to PHT or CBZ. Phenobarbital pretreatment appears to produce cross-tolerance to the effects of PRM.

KW - Antiepileptic drug

KW - Primidone

KW - Side effects

KW - Tolerance

KW - Toxicity

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ER -

Development of tolerance to the side effects of primidone

Abstract

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