Development of specific in vitro lymphocyte responses in cattle infected with Mycobacterium bovis and with Mycobacterium avium

Charles C Muscoplat, C. O. Thoen, A. Wu Chen, D. W. Johnson

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Two calves infected with Mycobacterium avium and another 2 with Mycobacterium bovis were studied for development and specificity of lymphocyte activation responses and skin reactivity to purified protein derivatives (PPD). Lymphocytes cultured in vitro from infected calves manifested significant uptake of tritiated thymidine in response to the PPD prepared from the homologous organisms, whereas heterologous PPD produced little or no stimulation. The time of appearance of specifically sensitized lymphocytes was studied, as was the specificity of skin reactivity.

Original languageEnglish (US)
Pages (from-to)395-398
Number of pages4
JournalAmerican journal of veterinary research
Volume36
Issue number4 I
StatePublished - Dec 1 1975

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