Development of resin-to-resin transfer reactions (RRTR) using Sonogashira chemistry

Judit Tulla-Puche, George Barany

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Sonogashira chemistry can be used according to the 'resin-to-resin transfer reaction' (RRTR) concept. Two fragments, one containing the halide moiety and the second one incorporating the alkyne functionality, are anchored on different solid supports using allyl and/or Wang-type linkages. Treatment with Pd(0) cleaves the allyl-linked fragment(s) which subsequently undergo Sonogashira coupling under the same conditions.

Original languageEnglish (US)
Pages (from-to)2195-2201
Number of pages7
Issue number8
StatePublished - Feb 21 2005

Bibliographical note

Funding Information:
We thank Professor Fernando Albericio for encouragement and critical reading of the manuscript. This work was supported by the NIH (GM 42722).

Copyright 2008 Elsevier B.V., All rights reserved.


  • Resin-to-resin transfer reactions
  • Solid-phase organic synthesis
  • Sonogashira coupling


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