Sonogashira chemistry can be used according to the 'resin-to-resin transfer reaction' (RRTR) concept. Two fragments, one containing the halide moiety and the second one incorporating the alkyne functionality, are anchored on different solid supports using allyl and/or Wang-type linkages. Treatment with Pd(0) cleaves the allyl-linked fragment(s) which subsequently undergo Sonogashira coupling under the same conditions.
Bibliographical noteFunding Information:
We thank Professor Fernando Albericio for encouragement and critical reading of the manuscript. This work was supported by the NIH (GM 42722).
Copyright 2008 Elsevier B.V., All rights reserved.
- Resin-to-resin transfer reactions
- Solid-phase organic synthesis
- Sonogashira coupling