TY - JOUR
T1 - Development of obesity in Zucker obese (fafa) rat in absence of hyperphagia.
AU - Cleary, M. P.
AU - Vasselli, J. R.
AU - Greenwood, M. R.
PY - 1980/3
Y1 - 1980/3
N2 - The free-feeding, genetically obese rat is hyperphagic, hyperinsulinemic, and hypertriglyceridemic and has increased fat cell size and number compared to its lean littermate. These experiments demonstrate that, when fafa rats are prevented from expressing hyperphagia throughout life, the complete obese "syndrome" still develops. Furthermore, life-long food restriction does not prevent increased lipoprotein lipase in the fafa rat. The data support the concept that a peripheral metabolic adaptation, probably in lipid metabolism, results in preferential shunting of dietary substrate in the restricted obese rats to adipose tissue with concomitant decreases in other tissues.
AB - The free-feeding, genetically obese rat is hyperphagic, hyperinsulinemic, and hypertriglyceridemic and has increased fat cell size and number compared to its lean littermate. These experiments demonstrate that, when fafa rats are prevented from expressing hyperphagia throughout life, the complete obese "syndrome" still develops. Furthermore, life-long food restriction does not prevent increased lipoprotein lipase in the fafa rat. The data support the concept that a peripheral metabolic adaptation, probably in lipid metabolism, results in preferential shunting of dietary substrate in the restricted obese rats to adipose tissue with concomitant decreases in other tissues.
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U2 - 10.1152/ajpendo.1980.238.3.e284
DO - 10.1152/ajpendo.1980.238.3.e284
M3 - Article
C2 - 7369356
AN - SCOPUS:4243603259
SN - 0002-9513
VL - 238
SP - E284-E292
JO - The American journal of physiology
JF - The American journal of physiology
IS - 3
ER -
