Development of obesity in Zucker obese (fafa) rat in absence of hyperphagia.

M. P. Cleary, J. R. Vasselli, M. R. Greenwood

Research output: Contribution to journalArticle

138 Scopus citations

Abstract

The free-feeding, genetically obese rat is hyperphagic, hyperinsulinemic, and hypertriglyceridemic and has increased fat cell size and number compared to its lean littermate. These experiments demonstrate that, when fafa rats are prevented from expressing hyperphagia throughout life, the complete obese "syndrome" still develops. Furthermore, life-long food restriction does not prevent increased lipoprotein lipase in the fafa rat. The data support the concept that a peripheral metabolic adaptation, probably in lipid metabolism, results in preferential shunting of dietary substrate in the restricted obese rats to adipose tissue with concomitant decreases in other tissues.

Original languageEnglish (US)
Pages (from-to)E284-E292
JournalThe American journal of physiology
Volume238
Issue number3
DOIs
StatePublished - Mar 1980

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