Development of mast cells and importance of their tryptase and chymase serine proteases in inflammation and wound healing

Jeffrey Douaiher, Julien Succar, Luca Lancerotto, Michael F. Gurish, Dennis P. Orgill, Matthew J. Hamilton, Steven A. Krilis, Richard L. Stevens

Research output: Contribution to journalArticle

84 Scopus citations

Abstract

Mast cells (MCs) are active participants in blood coagulation and innate and acquired immunity. This review focuses on the development of mouse and human MCs, as well as the involvement of their granule serine proteases in inflammation and the connective tissue remodeling that occurs during the different phases of the healing process of wounded skin and other organs. The accumulated data suggest that MCs, their tryptases, and their chymases play important roles in tissue repair. While MCs initially promote healing, they can be detrimental if they are chronically stimulated or if too many MCs become activated at the same time. The possibility that MCs and their granule serine proteases contribute to the formation of keloid and hypertrophic scars makes them potential targets for therapeutic intervention in the repair of damaged skin.

Original languageEnglish (US)
Pages (from-to)211-252
Number of pages42
JournalAdvances in Immunology
Volume122
DOIs
StatePublished - Feb 6 2014

Keywords

  • Chymase
  • Connective tissue remodeling
  • Inflammation
  • Mast cell
  • Matrix metalloproteinase
  • Serine protease
  • Tryptase
  • Wound healing

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    Douaiher, J., Succar, J., Lancerotto, L., Gurish, M. F., Orgill, D. P., Hamilton, M. J., Krilis, S. A., & Stevens, R. L. (2014). Development of mast cells and importance of their tryptase and chymase serine proteases in inflammation and wound healing. Advances in Immunology, 122, 211-252. https://doi.org/10.1016/B978-0-12-800267-4.00006-7