Development of Hippocampal-Prefrontal Cortex Interactions through Adolescence

Finnegan J. Calabro, Vishnu P. Murty, Maria Jalbrzikowski, Brenden Tervo-Clemmens, Beatriz Luna

Research output: Contribution to journalArticlepeer-review

64 Scopus citations


Significant improvements in cognitive control occur from childhood through adolescence, supported by the maturation of prefrontal systems. However, less is known about the neural basis of refinements in cognitive control proceeding from adolescence to adulthood. Accumulating evidence indicates that integration between hippocampus (HPC) and prefrontal cortex (PFC) supports flexible cognition and has a protracted neural maturation. Using a longitudinal design (487 scans), we characterized developmental changes from 8 to 32 years of age in HPC-PFC functional connectivity at rest and its associations with cognitive development. Results indicated significant increases in functional connectivity between HPC and ventromedial PFC (vmPFC), but not dorsolateral PFC. Importantly, HPC-vmPFC connectivity exclusively predicted performance on the Stockings of Cambridge task, which probes problem solving and future planning. These data provide evidence that maturation of high-level cognition into adulthood is supported by increased functional integration across the HPC and vmPFC through adolescence.

Original languageEnglish (US)
Pages (from-to)1548-1558
Number of pages11
JournalCerebral Cortex
Issue number3
StatePublished - Mar 14 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2019 The Author(s) 2019. Published by Oxford University Press. All rights reserved. For permissions, please e-mail:


  • adolescence
  • executive function
  • hippocampus
  • prefrontal cortex
  • resting state


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