Imidazolium salts are shown to catalyze the rapid room temperature reaction of indoles or naphthol with aldehydes to provide bis(indolyl)methanes or bis(naphthol)methane in excellent yields and the reaction proceeds optimally in dichloromethane with no base additives. The reaction exhibits a broad substrate tolerance and occurs through nucleophilic activation of the indoles and naphthols through a cation–π interaction.
|Original language||English (US)|
|State||Published - Apr 2019|
Bibliographical noteFunding Information:
This work was supported by the grant of The State Key Laboratory of Bioactive Substance and Function of Natural Medicines (SKLBSFNM) and by the Union Scholar Chair Professor in Institute Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College (PUMC) to C.C.A. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
© 2019 Wang, Aldrich. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.