DEVELOPMENT OF AN EPICARDIAL MAPPING TANK FOR NONINVASIVE ELECTRICAL MAPPING OF EX VIVO LARGE MAMMALIAN HEARTS

Renee C. Brigham; Erik R. Donley; Paul A. Iaizzo

doi:10.1115/dmd2022-1069

DEVELOPMENT OF AN EPICARDIAL MAPPING TANK FOR NONINVASIVE ELECTRICAL MAPPING OF EX VIVO LARGE MAMMALIAN HEARTS

Renee C. Brigham, Erik R. Donley, Paul A. Iaizzo

Surgery

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Electroanatomical mapping provides key insights into cardiac function and arrhythmia location. Epicardial mapping allows for the recording of electrograms from the body surface that can be combined with an anatomical geometry to create a real-time functional voltage map of cardiac electrical activity. Isolated heart models, like those studied on the Visible Heart® apparatus, provide a valuable platform for medical device design but are often limited to modified 3-lead electrocardiograms that do not provide anatomically specific electrical data. To provide detailed electroanatomical data for experiments on the Visible Heart® apparatus, a novel modified epicardial mapping tank was created that utilizes the CardioInsight™ software to create a map of reanimated hearts. The epicardial mapping tank is composed of 252 electrodes that are distributed across acrylic plates that surround the isolated heart. Half normal saline provides continuity to the electrodes, allowing uninterrupted signal acquisition. The system is fully removable and can be positioned while maintaining reanimation. To date, 5 swine hearts and 1 human heart have been reanimated and mapped in the epicardial mapping tank. The unique datasets generated from the epicardial mapping chamber will be a critical tool in pacing, ablation, and defibrillation experiments as well as provide valuable information relative to conduction system physiology.

Original language	English (US)
Title of host publication	Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022
Publisher	American Society of Mechanical Engineers
ISBN (Electronic)	9780791885710
DOIs	https://doi.org/10.1115/dmd2022-1069
State	Published - 2022
Event	2022 Design of Medical Devices Conference, DMD 2022 - Minneapolis, Virtual, United States Duration: Apr 11 2022 → Apr 14 2022

Publication series

Name	Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022

Conference

Conference	2022 Design of Medical Devices Conference, DMD 2022
Country/Territory	United States
City	Minneapolis, Virtual
Period	4/11/22 → 4/14/22

Bibliographical note

Funding Information:
We would like to acknowledge LifeSource and the donors for the human hearts used in this study. We would also like to thank Mark Borash, the other graduate students within the VHL, and Dr. Tinen Iles for feedback on early prototype designs.

Publisher Copyright:
© 2022 by ASME

Keywords

Electroanatomical mapping
electrophysiological recording system
isolated heart models

Publisher link

10.1115/dmd2022-1069

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Cite this

Brigham, R. C., Donley, E. R., & Iaizzo, P. A. (2022). DEVELOPMENT OF AN EPICARDIAL MAPPING TANK FOR NONINVASIVE ELECTRICAL MAPPING OF EX VIVO LARGE MAMMALIAN HEARTS. In Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022 Article V001T01A006 (Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022). American Society of Mechanical Engineers. https://doi.org/10.1115/dmd2022-1069

DEVELOPMENT OF AN EPICARDIAL MAPPING TANK FOR NONINVASIVE ELECTRICAL MAPPING OF EX VIVO LARGE MAMMALIAN HEARTS. / Brigham, Renee C.; Donley, Erik R.; Iaizzo, Paul A.
Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022. American Society of Mechanical Engineers, 2022. V001T01A006 (Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Brigham, RC, Donley, ER & Iaizzo, PA 2022, DEVELOPMENT OF AN EPICARDIAL MAPPING TANK FOR NONINVASIVE ELECTRICAL MAPPING OF EX VIVO LARGE MAMMALIAN HEARTS. in Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022., V001T01A006, Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022, American Society of Mechanical Engineers, 2022 Design of Medical Devices Conference, DMD 2022, Minneapolis, Virtual, United States, 4/11/22. https://doi.org/10.1115/dmd2022-1069

Brigham RC, Donley ER, Iaizzo PA. DEVELOPMENT OF AN EPICARDIAL MAPPING TANK FOR NONINVASIVE ELECTRICAL MAPPING OF EX VIVO LARGE MAMMALIAN HEARTS. In Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022. American Society of Mechanical Engineers. 2022. V001T01A006. (Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022). doi: 10.1115/dmd2022-1069

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DEVELOPMENT OF AN EPICARDIAL MAPPING TANK FOR NONINVASIVE ELECTRICAL MAPPING OF EX VIVO LARGE MAMMALIAN HEARTS

Abstract

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Bibliographical note

Keywords

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