Development of a vaccine-challenge model for avian metapneumovirus subtype C in turkeys

Binu T. Velayudhan, Sally L. Noll, Anil J. Thachil, Daniel P. Shaw, Sagar M. Goyal, David A. Halvorson, Kakambi V. Nagaraja

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The objective of this study was to evaluate different preparations of avian metapneumovirus (aMPV) subtype C as vaccine challenge in turkeys. Two aMPV isolates and their respective nasal turbinate homogenates after propagation in turkeys were used in the study. Significantly higher clinical sign scores were recorded in birds inoculated with 20 or 2% turbinate homogenate of recent isolate. Birds in the above groups showed more pronounced histopathological lesions, and a higher percentage of birds showed viral RNA and antigen in tissues. The data demonstrated that nasal turbinate homogenate of recent isolate produced severe clinical signs and lesions in turkeys and could be an ideal candidate for vaccine-challenge studies.

Original languageEnglish (US)
Pages (from-to)1841-1847
Number of pages7
JournalVaccine
Volume25
Issue number10
DOIs
StatePublished - Feb 26 2007

Keywords

  • Avian metapneumovirus
  • Challenge
  • Turbinate
  • Turkey

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