Development of a standardized transfusion ratio as a metric for evaluating dialysis facility anemia management practices

Jiannong Liu, Suying Li, David T. Gilbertson, Keri L. Monda, Brian D. Bradbury, Allan J. Collins

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Background Because transfusion avoidance has been the cornerstone of anemia treatment for patients with kidney disease, direct measurement of red blood cell transfusion use to assess dialysis facility anemia management performance is reasonable. We aimed to explore methods for estimating facility-level standardized transfusion ratios (STfRs) to assess provider anemia treatment practices.

Study Design Retrospective cohort study.

Setting & Participants Point prevalent US hemodialysis patients on January 1, 2009, with Medicare as primary payer and dialysis duration of 90 days or longer were included (n = 223,901). All dialysis facilities with eligible patients were included (n = 5,345).

Predictor Dialysis facility assignment.

Results The overall national transfusion rate in 2009 was 23.2 per 100 patient-years. Our model for predicting the expected number of transfusions performed well. For large facilities, all 3 STfRs worked well. However, for small facilities, while the STfRmodBayes worked well, STfRobs values demonstrated instability and the STfRBayes may produce more bias.

Limitations Administration of transfusions to dialysis patients reflects medical practice both within and outside the dialysis unit. Some transfusions may be deemed unavoidable and transfusion practices are subject to considerable regional variation.

Outcome Receiving a red blood cell transfusion in the inpatient or outpatient setting.

Measurements We evaluated 3 approaches for estimating STfR: ratio of observed to expected numbers of transfusions (STfRobs), a Bayesian approach (STfRBayes), and a modified version of the Bayesian approach (STfRmodBayes).

Conclusions Development of an STfR metric is feasible and reasonable for assessing anemia treatment at dialysis facilities. The STfRobs is simple to calculate and works well for larger dialysis facilities. The STfRmodBayes is more analytically complex, but facilitates comparisons across all dialysis facilities, including small facilities.

Original languageEnglish (US)
Pages (from-to)608-615
Number of pages8
JournalAmerican Journal of Kidney Diseases
Issue number4
StatePublished - Oct 1 2014

Bibliographical note

Publisher Copyright:
© 2014 National Kidney Foundation, Inc.


  • Anemia
  • Bayesian approach
  • anemia management
  • dialysis
  • end-stage renal disease (ESRD)
  • facility-level practice
  • standardized ratio
  • transfusion


Dive into the research topics of 'Development of a standardized transfusion ratio as a metric for evaluating dialysis facility anemia management practices'. Together they form a unique fingerprint.

Cite this