Development of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L-A hybrid design approach

Dibyendu Dana, Shatarupa De, Pratikkumar Rathod, Anibal R. Davalos, Daniel A. Novoa, Suneeta Paroly, Viviana M. Torres, Nisar Afzal, Ravi S. Lankalapalli, Susan A. Rotenberg, Emmanuel J. Chang, Gopal Subramaniam, Sanjai Kumar

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

A hybrid-design approach is undertaken to develop a highly potent and selective inhibitor of human cathepsin L. Studies involving human breast carcinoma MDA-MB-231 cells establish that this inhibitor can successfully block intracellular cathepsin L activity, and retard the cell-migratory potential of these highly metastatic cells.

Original languageEnglish (US)
Pages (from-to)10875-10878
Number of pages4
JournalChemical Communications
Volume50
Issue number74
DOIs
StatePublished - Sep 25 2014

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