Development of a DNA Adductome Mass Spectral Database

Jingshu Guo; Robert J. Turesky; Anamary Tarifa; Anthony P. Decaprio; Marcus S. Cooke; Scott J. Walmsley; Peter W. Villalta

doi:10.1021/acs.chemrestox.0c00031

Development of a DNA Adductome Mass Spectral Database

Jingshu Guo, Robert J. Turesky, Anamary Tarifa, Anthony P. Decaprio, Marcus S. Cooke, Scott J. Walmsley, Peter W. Villalta

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Mass spectrometry-based DNA adductomics is an emerging approach for the human biomonitoring of hazardous chemicals. A mass spectral database of DNA adducts will be created for the scientific community to investigate the associations between chemical exposures, DNA damage, and disease risk.

Original language	English (US)
Pages (from-to)	852-854
Number of pages	3
Journal	Chemical research in toxicology
Volume	33
Issue number	4
DOIs	https://doi.org/10.1021/acs.chemrestox.0c00031
State	Published - Apr 20 2020

Bibliographical note

Funding Information:
This work is supported by R03ES031188 (JG), R01CA220367 and R01ES019564 (RJT), and R50CA211256 (PWV). The mass spectrometry performed using the Orbitrap instrumentation was conducted in the Analytical Biochemistry Shared Resource of the Masonic Cancer Center, the University of Minnesota, funded in part by Cancer Center Support Grant CA077598. We would like to thank Drs. Oliver Fiehn, David Wishart, and Tim Stratton for their cooperation and assistance with the submission of spectra to the MoNA, HMDB, and mzCloud databases, respectively.

Publisher Copyright:
© 2020 American Chemical Society.

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10.1021/acs.chemrestox.0c00031

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title = "Development of a DNA Adductome Mass Spectral Database",

abstract = "Mass spectrometry-based DNA adductomics is an emerging approach for the human biomonitoring of hazardous chemicals. A mass spectral database of DNA adducts will be created for the scientific community to investigate the associations between chemical exposures, DNA damage, and disease risk.",

author = "Jingshu Guo and Turesky, {Robert J.} and Anamary Tarifa and Decaprio, {Anthony P.} and Cooke, {Marcus S.} and Walmsley, {Scott J.} and Villalta, {Peter W.}",

note = "Funding Information: This work is supported by R03ES031188 (JG), R01CA220367 and R01ES019564 (RJT), and R50CA211256 (PWV). The mass spectrometry performed using the Orbitrap instrumentation was conducted in the Analytical Biochemistry Shared Resource of the Masonic Cancer Center, the University of Minnesota, funded in part by Cancer Center Support Grant CA077598. We would like to thank Drs. Oliver Fiehn, David Wishart, and Tim Stratton for their cooperation and assistance with the submission of spectra to the MoNA, HMDB, and mzCloud databases, respectively. Publisher Copyright: {\textcopyright} 2020 American Chemical Society.",

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doi = "10.1021/acs.chemrestox.0c00031",

language = "English (US)",

volume = "33",

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AU - Guo, Jingshu

AU - Turesky, Robert J.

AU - Tarifa, Anamary

AU - Decaprio, Anthony P.

AU - Cooke, Marcus S.

AU - Walmsley, Scott J.

AU - Villalta, Peter W.

N1 - Funding Information: This work is supported by R03ES031188 (JG), R01CA220367 and R01ES019564 (RJT), and R50CA211256 (PWV). The mass spectrometry performed using the Orbitrap instrumentation was conducted in the Analytical Biochemistry Shared Resource of the Masonic Cancer Center, the University of Minnesota, funded in part by Cancer Center Support Grant CA077598. We would like to thank Drs. Oliver Fiehn, David Wishart, and Tim Stratton for their cooperation and assistance with the submission of spectra to the MoNA, HMDB, and mzCloud databases, respectively. Publisher Copyright: © 2020 American Chemical Society.

PY - 2020/4/20

Y1 - 2020/4/20

N2 - Mass spectrometry-based DNA adductomics is an emerging approach for the human biomonitoring of hazardous chemicals. A mass spectral database of DNA adducts will be created for the scientific community to investigate the associations between chemical exposures, DNA damage, and disease risk.

AB - Mass spectrometry-based DNA adductomics is an emerging approach for the human biomonitoring of hazardous chemicals. A mass spectral database of DNA adducts will be created for the scientific community to investigate the associations between chemical exposures, DNA damage, and disease risk.

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Development of a DNA Adductome Mass Spectral Database

Abstract

Bibliographical note

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