Development of a DNA Adductome Mass Spectral Database

Jingshu Guo, Robert J. Turesky, Anamary Tarifa, Anthony P. Decaprio, Marcus S. Cooke, Scott J. Walmsley, Peter W. Villalta

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Mass spectrometry-based DNA adductomics is an emerging approach for the human biomonitoring of hazardous chemicals. A mass spectral database of DNA adducts will be created for the scientific community to investigate the associations between chemical exposures, DNA damage, and disease risk.

Original languageEnglish (US)
Pages (from-to)852-854
Number of pages3
JournalChemical research in toxicology
Issue number4
StatePublished - Apr 20 2020

Bibliographical note

Funding Information:
This work is supported by R03ES031188 (JG), R01CA220367 and R01ES019564 (RJT), and R50CA211256 (PWV). The mass spectrometry performed using the Orbitrap instrumentation was conducted in the Analytical Biochemistry Shared Resource of the Masonic Cancer Center, the University of Minnesota, funded in part by Cancer Center Support Grant CA077598. We would like to thank Drs. Oliver Fiehn, David Wishart, and Tim Stratton for their cooperation and assistance with the submission of spectra to the MoNA, HMDB, and mzCloud databases, respectively.

Publisher Copyright:
© 2020 American Chemical Society.


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