Mass spectrometry-based DNA adductomics is an emerging approach for the human biomonitoring of hazardous chemicals. A mass spectral database of DNA adducts will be created for the scientific community to investigate the associations between chemical exposures, DNA damage, and disease risk.
|Original language||English (US)|
|Number of pages||3|
|Journal||Chemical research in toxicology|
|State||Published - Apr 20 2020|
Bibliographical noteFunding Information:
This work is supported by R03ES031188 (JG), R01CA220367 and R01ES019564 (RJT), and R50CA211256 (PWV). The mass spectrometry performed using the Orbitrap instrumentation was conducted in the Analytical Biochemistry Shared Resource of the Masonic Cancer Center, the University of Minnesota, funded in part by Cancer Center Support Grant CA077598. We would like to thank Drs. Oliver Fiehn, David Wishart, and Tim Stratton for their cooperation and assistance with the submission of spectra to the MoNA, HMDB, and mzCloud databases, respectively.
© 2020 American Chemical Society.