DEVELOPMENT OF A DILATED CARDIOMYOPATHY HEART FAILURE MODEL EMPLOYING HIGH-RATE PACING VIA AN IMPLANTABLE LEADLESS PACEMAKER: UTILIZED FOR IN SITU AND EX VIVO INVESTIGATIONS

Emma Schinstock; Michael Bielecki; Kudlik D'Anne; Michael Eggen; Paul A. Iaizzo

doi:10.1115/dmd2022-1064

DEVELOPMENT OF A DILATED CARDIOMYOPATHY HEART FAILURE MODEL EMPLOYING HIGH-RATE PACING VIA AN IMPLANTABLE LEADLESS PACEMAKER: UTILIZED FOR IN SITU AND EX VIVO INVESTIGATIONS

Emma Schinstock, Michael Bielecki, Kudlik D'Anne, Michael Eggen, Paul A. Iaizzo

Surgery

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Isolated heart failure models are valuable to researchers for multiple uses, including device design. Currently, models often use artificial materials and/or simulated pulsatile pre-clinical models or alternatively, employ animal models which often present obstacles to gaining access to the heart. The Visible Heart^® apparatus allows researchers to benefit from a live tissue model while increasing access to the heart and adding the abilities to directly visualize the anatomic effects of a therapy or device. This work presents the development of a model to mimic dilated cardiomyopathy in humans by utilizing rapid pacing in swine and subsequently reanimating the heart on the Visible Heart^® apparatus. This heart failure model allowed for functional assessments, multimodal imaging, and the administrations of various therapeutic approaches.

Original language	English (US)
Title of host publication	Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022
Publisher	American Society of Mechanical Engineers
ISBN (Electronic)	9780791885710
DOIs	https://doi.org/10.1115/dmd2022-1064
State	Published - 2022
Event	2022 Design of Medical Devices Conference, DMD 2022 - Minneapolis, Virtual, United States Duration: Apr 11 2022 → Apr 14 2022

Publication series

Name	Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022

Conference

Conference	2022 Design of Medical Devices Conference, DMD 2022
Country/Territory	United States
City	Minneapolis, Virtual
Period	4/11/22 → 4/14/22

Bibliographical note

Funding Information:
The authors would like to acknowledge the visible heart lab PhD students for helping to facilitate this research and the staff at research animal resources at the University of Minnesota.

Publisher Copyright:
© 2022 by ASME

Keywords

Heart failure
reanimation
swine

Publisher link

10.1115/dmd2022-1064

Find It

Find It at U of M Libraries

Cite this

Schinstock, E., Bielecki, M., D'Anne, K., Eggen, M., & Iaizzo, P. A. (2022). DEVELOPMENT OF A DILATED CARDIOMYOPATHY HEART FAILURE MODEL EMPLOYING HIGH-RATE PACING VIA AN IMPLANTABLE LEADLESS PACEMAKER: UTILIZED FOR IN SITU AND EX VIVO INVESTIGATIONS. In Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022 Article V001T01A005 (Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022). American Society of Mechanical Engineers. https://doi.org/10.1115/dmd2022-1064

DEVELOPMENT OF A DILATED CARDIOMYOPATHY HEART FAILURE MODEL EMPLOYING HIGH-RATE PACING VIA AN IMPLANTABLE LEADLESS PACEMAKER: UTILIZED FOR IN SITU AND EX VIVO INVESTIGATIONS. / Schinstock, Emma; Bielecki, Michael; D'Anne, Kudlik et al.
Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022. American Society of Mechanical Engineers, 2022. V001T01A005 (Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Schinstock, E, Bielecki, M, D'Anne, K, Eggen, M & Iaizzo, PA 2022, DEVELOPMENT OF A DILATED CARDIOMYOPATHY HEART FAILURE MODEL EMPLOYING HIGH-RATE PACING VIA AN IMPLANTABLE LEADLESS PACEMAKER: UTILIZED FOR IN SITU AND EX VIVO INVESTIGATIONS. in Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022., V001T01A005, Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022, American Society of Mechanical Engineers, 2022 Design of Medical Devices Conference, DMD 2022, Minneapolis, Virtual, United States, 4/11/22. https://doi.org/10.1115/dmd2022-1064

Schinstock E, Bielecki M, D'Anne K, Eggen M, Iaizzo PA. DEVELOPMENT OF A DILATED CARDIOMYOPATHY HEART FAILURE MODEL EMPLOYING HIGH-RATE PACING VIA AN IMPLANTABLE LEADLESS PACEMAKER: UTILIZED FOR IN SITU AND EX VIVO INVESTIGATIONS. In Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022. American Society of Mechanical Engineers. 2022. V001T01A005. (Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022). doi: 10.1115/dmd2022-1064

Schinstock, Emma ; Bielecki, Michael ; D'Anne, Kudlik et al. / DEVELOPMENT OF A DILATED CARDIOMYOPATHY HEART FAILURE MODEL EMPLOYING HIGH-RATE PACING VIA AN IMPLANTABLE LEADLESS PACEMAKER : UTILIZED FOR IN SITU AND EX VIVO INVESTIGATIONS. Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022. American Society of Mechanical Engineers, 2022. (Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022).

@inproceedings{bc1af478ef584d769e703b0096efaf2d,

title = "DEVELOPMENT OF A DILATED CARDIOMYOPATHY HEART FAILURE MODEL EMPLOYING HIGH-RATE PACING VIA AN IMPLANTABLE LEADLESS PACEMAKER: UTILIZED FOR IN SITU AND EX VIVO INVESTIGATIONS",

abstract = "Isolated heart failure models are valuable to researchers for multiple uses, including device design. Currently, models often use artificial materials and/or simulated pulsatile pre-clinical models or alternatively, employ animal models which often present obstacles to gaining access to the heart. The Visible Heart{\textregistered} apparatus allows researchers to benefit from a live tissue model while increasing access to the heart and adding the abilities to directly visualize the anatomic effects of a therapy or device. This work presents the development of a model to mimic dilated cardiomyopathy in humans by utilizing rapid pacing in swine and subsequently reanimating the heart on the Visible Heart{\textregistered} apparatus. This heart failure model allowed for functional assessments, multimodal imaging, and the administrations of various therapeutic approaches.",

keywords = "Heart failure, reanimation, swine",

author = "Emma Schinstock and Michael Bielecki and Kudlik D'Anne and Michael Eggen and Iaizzo, {Paul A.}",

note = "Funding Information: The authors would like to acknowledge the visible heart lab PhD students for helping to facilitate this research and the staff at research animal resources at the University of Minnesota. Publisher Copyright: {\textcopyright} 2022 by ASME; 2022 Design of Medical Devices Conference, DMD 2022 ; Conference date: 11-04-2022 Through 14-04-2022",

year = "2022",

doi = "10.1115/dmd2022-1064",

language = "English (US)",

series = "Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022",

publisher = "American Society of Mechanical Engineers",

booktitle = "Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022",

}

TY - GEN

T1 - DEVELOPMENT OF A DILATED CARDIOMYOPATHY HEART FAILURE MODEL EMPLOYING HIGH-RATE PACING VIA AN IMPLANTABLE LEADLESS PACEMAKER

T2 - 2022 Design of Medical Devices Conference, DMD 2022

AU - Schinstock, Emma

AU - Bielecki, Michael

AU - D'Anne, Kudlik

AU - Eggen, Michael

AU - Iaizzo, Paul A.

N1 - Funding Information: The authors would like to acknowledge the visible heart lab PhD students for helping to facilitate this research and the staff at research animal resources at the University of Minnesota. Publisher Copyright: © 2022 by ASME

PY - 2022

Y1 - 2022

N2 - Isolated heart failure models are valuable to researchers for multiple uses, including device design. Currently, models often use artificial materials and/or simulated pulsatile pre-clinical models or alternatively, employ animal models which often present obstacles to gaining access to the heart. The Visible Heart® apparatus allows researchers to benefit from a live tissue model while increasing access to the heart and adding the abilities to directly visualize the anatomic effects of a therapy or device. This work presents the development of a model to mimic dilated cardiomyopathy in humans by utilizing rapid pacing in swine and subsequently reanimating the heart on the Visible Heart® apparatus. This heart failure model allowed for functional assessments, multimodal imaging, and the administrations of various therapeutic approaches.

AB - Isolated heart failure models are valuable to researchers for multiple uses, including device design. Currently, models often use artificial materials and/or simulated pulsatile pre-clinical models or alternatively, employ animal models which often present obstacles to gaining access to the heart. The Visible Heart® apparatus allows researchers to benefit from a live tissue model while increasing access to the heart and adding the abilities to directly visualize the anatomic effects of a therapy or device. This work presents the development of a model to mimic dilated cardiomyopathy in humans by utilizing rapid pacing in swine and subsequently reanimating the heart on the Visible Heart® apparatus. This heart failure model allowed for functional assessments, multimodal imaging, and the administrations of various therapeutic approaches.

KW - Heart failure

KW - reanimation

KW - swine

UR - http://www.scopus.com/inward/record.url?scp=85130280572&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85130280572&partnerID=8YFLogxK

U2 - 10.1115/dmd2022-1064

DO - 10.1115/dmd2022-1064

M3 - Conference contribution

AN - SCOPUS:85130280572

T3 - Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022

BT - Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022

PB - American Society of Mechanical Engineers

Y2 - 11 April 2022 through 14 April 2022

ER -

DEVELOPMENT OF A DILATED CARDIOMYOPATHY HEART FAILURE MODEL EMPLOYING HIGH-RATE PACING VIA AN IMPLANTABLE LEADLESS PACEMAKER: UTILIZED FOR IN SITU AND EX VIVO INVESTIGATIONS

Abstract

Publication series

Conference

Bibliographical note

Keywords

Publisher link

Find It

Other files and links

Fingerprint

Cite this