Development and validation of an ankle brachial index risk model for the prediction of cardiovascular events

F. G R Fowkes, G. D. Murray, I. Butcher, A. R. Folsom, A. T. Hirsch, D. J. Couper, G. Debacker, M. Kornitzer, A. B. Newman, K. C. Sutton-Tyrrell, M. Cushman, A. J. Lee, J. F. Price, R. B. D'Agostino, J. M. Murabito, P. E. Norman, K. H. Masaki, L. M. Bouter, R. J. Heine, C. D A StehouwerM. M. McDermott, H. E J H Stoffers, J. A. Knottnerus, M. Ogren, B. Hedblad, W. Koenig, C. Meisinger, J. A. Cauley, O. H. Franco, M. G M Hunink, A. Hofman, J. C. Witteman, M. H. Criqui, R. D. Langer, W. R. Hiatt, R. F. Hamman

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


Background: The ankle brachial index (ABI) is related to risk of cardiovascular events independent of the Framingham risk score (FRS). The aim of this study was to develop and evaluate a risk model for cardiovascular events incorporating the ABI and FRS. Design: An analysis of participant data from 18 cohorts in which 24,375 men and 20,377 women free of coronary heart disease had ABI measured and were followed up for events. Methods: Subjects were divided into a development and internal validation dataset and an external validation dataset. Two models, comprising FRS and FRS+ABI, were fitted for the primary outcome of major coronary events.

Original languageEnglish (US)
Pages (from-to)310-320
Number of pages11
JournalEuropean Journal of Preventive Cardiology
Issue number3
StatePublished - Mar 2014

Bibliographical note

Funding Information:
The ARIC study was supported by the National Heart, Lung, and Blood Institute (contracts HHSN268201100005C, -06C, -07C, -08C, -09C, -10C, -11C, and -12C).


  • Ankle brachial index
  • cardiovascular diseases
  • risk assessment


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