Development and Validation of a Multi-institutional Preoperative Nomogram for Predicting Grade of Dysplasia in Intraductal Papillary Mucinous Neoplasms (IPMNs) of the Pancreas

Marc A. Attiyeh, Carlos Fernández-Del Castillo, Mohammad Al Efishat, Anne A. Eaton, Mithat Gönen, Ruqayyah Batts, Ilaria Pergolini, Neda Rezaee, Keith D. Lillemoe, Cristina R. Ferrone, Mari Mino-Kenudson, Matthew J. Weiss, John L. Cameron, Ralph H. Hruban, Michael I. D'Angelica, Ronald P. Dematteo, T. Peter Kingham, William R. Jarnagin, Christopher L. Wolfgang, Peter J. Allen

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28 Scopus citations

Abstract

Objective: Previous nomogram models for patients undergoing resection of intraductal papillary mucinous neoplasms (IPMNs) have been relatively small single-institutional series. Our objective was to improve upon these studies by developing and independently validating a new model using a large multiinstitutional dataset. Summary Background Data: IPMNs represent the most common radiographically identifiable precursor lesions of pancreatic cancer. They are a heterogenous group of neoplasms in which more accurate markers of high-grade dysplasia or early invasive carcinoma could help avoid unnecessary surgery in 1 case and support potentially curative intervention (resection) in another. Methods: Prospectively maintained databases from 3 institutions were queried for patients who had undergone resection of IPMNs between 2005 and 2015. Patients were separated into main duct [main and mixed-type (MD)] and branch duct (BD) types based on preoperative imaging. Logistic regression modeling was used on a training subset to develop 2 independent nomograms (MD and BD) to predict low-risk (low-or intermediate-grade dysplasia) or high-risk (high-grade dysplasia or invasive carcinoma) disease. Model performance was then evaluated using an independent validation set. Results: We identified 1028 patients who underwent resection for IPMNs [MD: N = 454 (44%), BD: N = 574 (56%)] during the 10-year study period. High-risk disease was present in 487 patients (47%). Patients with high-risk disease comprised 71% and 29% of MD and BD groups, respectively (P <0.0001). MD and BD nomograms were developed on the training set [70% of total (n = 720); MD: N = 318, BD: N = 402] and validated on the test set [30% (n = 308); MD: N = 136, BD: N = 172]. The presence of jaundice was almost exclusively associated with high-risk disease (57 of 58 patients, 98%). Cyst size >3.0cm, solid component/mural nodule, pain symptoms, and weight loss were significantly associated with high-risk disease. C-indices were 0.82 and 0.81 on training and independent validation sets, respectively; Brier scores were 0.173 and 0.175, respectively. Conclusions: For patients with suspected IPMNs, we present an independently validated model for the prediction of high-risk disease.

Original languageEnglish (US)
Pages (from-to)157-163
Number of pages7
JournalAnnals of surgery
Volume267
Issue number1
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

Keywords

  • cancer
  • dysplasia
  • intraductal papillary mucinous neoplasm
  • IPMN
  • nomogram
  • pancreas
  • the pancreatic surgery consortium

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    Attiyeh, M. A., Fernández-Del Castillo, C., Al Efishat, M., Eaton, A. A., Gönen, M., Batts, R., Pergolini, I., Rezaee, N., Lillemoe, K. D., Ferrone, C. R., Mino-Kenudson, M., Weiss, M. J., Cameron, J. L., Hruban, R. H., D'Angelica, M. I., Dematteo, R. P., Kingham, T. P., Jarnagin, W. R., Wolfgang, C. L., & Allen, P. J. (2018). Development and Validation of a Multi-institutional Preoperative Nomogram for Predicting Grade of Dysplasia in Intraductal Papillary Mucinous Neoplasms (IPMNs) of the Pancreas. Annals of surgery, 267(1), 157-163. https://doi.org/10.1097/SLA.0000000000002015