Development and deployment of COVID-19 vaccines forthose most vulnerable

Wayne C. Koff; Theodore Schenkelberg; Tere Williams; Ralph S. Baric; McDermott Adrian McDermott; Cheryl M. Cameron; Mark J. Cameron; Matthew B. Friemann; Gabriele Neumann; Yoshihiro Kawaoka; Alyson A. Kelvin; Ted M. Ross; Stacey Schultz-Cherry; Timothy D. Mastro; Frances H. Priddy; Kristine A. Moore; Julia T. Ostrowsky; Michael T. Osterholm; Jaap Goudsmit

doi:10.1126/scitranslmed.abd1525

Development and deployment of COVID-19 vaccines forthose most vulnerable

Wayne C. Koff, Theodore Schenkelberg, Tere Williams, Ralph S. Baric, McDermott Adrian McDermott, Cheryl M. Cameron, Mark J. Cameron, Matthew B. Friemann, Gabriele Neumann, Yoshihiro Kawaoka, Alyson A. Kelvin, Ted M. Ross, Stacey Schultz-Cherry, Timothy D. Mastro, Frances H. Priddy, Kristine A. Moore, Julia T. Ostrowsky, Michael T. Osterholm, Jaap Goudsmit

Research output: Contribution to journal › Review article › peer-review

63 Scopus citations

Abstract

Development of safe and effective COVID-19 vaccines is a global priority and the best hope for ending the COVID-19 pandemic. Remarkably, in less than 1 year, vaccines have been developed and shown to be efficacious and are already being deployed worldwide. Yet, many challenges remain. Immune senescence and comorbidities in aging populations and immune dysregulation in populations living in low-resource settings may impede vaccine effectiveness. Distribution of vaccines among these populations where vaccine access is historically low remains challenging. In this Review, we address these challenges and provide strategies for ensuring that vaccines are developed and deployed for those most vulnerable.

Original language	English (US)
Article number	eabd1525
Journal	Science Translational Medicine
Volume	13
Issue number	579
DOIs	https://doi.org/10.1126/scitranslmed.abd1525
State	Published - Feb 3 2021

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Publisher Copyright:
Copyright © 2021 The Authors.

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1126/scitranslmed.abd1525

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Koff, W. C., Schenkelberg, T., Williams, T., Baric, R. S., Adrian McDermott, M., Cameron, C. M., Cameron, M. J., Friemann, M. B., Neumann, G., Kawaoka, Y., Kelvin, A. A., Ross, T. M., Schultz-Cherry, S., Mastro, T. D., Priddy, F. H., Moore, K. A., Ostrowsky, J. T., Osterholm, M. T., & Goudsmit, J. (2021). Development and deployment of COVID-19 vaccines forthose most vulnerable. Science Translational Medicine, 13(579), Article eabd1525. https://doi.org/10.1126/scitranslmed.abd1525

Koff, WC, Schenkelberg, T, Williams, T, Baric, RS, Adrian McDermott, M, Cameron, CM, Cameron, MJ, Friemann, MB, Neumann, G, Kawaoka, Y, Kelvin, AA, Ross, TM, Schultz-Cherry, S, Mastro, TD, Priddy, FH, Moore, KA, Ostrowsky, JT , Osterholm, MT & Goudsmit, J 2021, 'Development and deployment of COVID-19 vaccines forthose most vulnerable', Science Translational Medicine, vol. 13, no. 579, eabd1525. https://doi.org/10.1126/scitranslmed.abd1525

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Development and deployment of COVID-19 vaccines forthose most vulnerable

Abstract

Bibliographical note

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